Mouse

The 3Hs Initiative—Housing, handling, and habituation

We have looked at our housing, handling and habituation approaches to identify areas to make improvements. This is critical for our resaerch outputs and has the benefit of reducing the cumulative suffering the animals experience by reducing stress and negative...

Year Published: 2024Topics: Animal Training, Drug/Substance Administration, Handling, Housing, RestraintAnimal Type: Mouse, Rat, Rodent

Citation: Bartlett, J., Hinchcliffe, J., Jackson, M. et al. 2024. The 3Hs Initiative—Housing, handling, and habituation. Animal Technology and Welfare 23(2), 91–99.

Comparison of two bedding types on the breeding fecundity of C57BL/6J mice

One of the favored options for generating complex transgenic laboratory mice is through in-house breeding and management strategies. One consideration in the management of these colonies is how the animals' environment may affect reproductive success. Several aspects of the microenvironment...

Year Published: 2024Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Pinckard, J. L., Gibson, L. A., Williams, W. R. 2024. Comparison of two bedding types on the breeding fecundity of C57BL/6J mice. Laboratory Animals 58(6), 545–551.

Adaptive wheel exercise for mouse models of Parkinson’s Disease

Background: Physical exercise has been extensively studied for its therapeutic properties in neurological disease, particularly Parkinson's Disease (PD). However, the established techniques for exercise in mice are not well suited to motor-deficient disease-model animals, rely on spontaneous activity or force...

Year Published: 2025Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Skelton, H., Grogan, D., Kotlure, A. et al. 2025. Adaptive wheel exercise for mouse models of Parkinson's Disease. Journal of Neuroscience Methods 414, 110314.

An exploration of the postural, location- and social contact- related sub-characteristics of inactive but awake behaviour as a depression-like indicator in mice

Inactive behaviour is essential to life. However, specific forms of inactivity may be indicative of compromised welfare in certain captive conditions. Inactive but awake behaviour (IBA - spontaneous, motionless awake behaviour without interacting with the surroundings) has been documented in...

Year Published: 2024Topics: Emotion, Pain, & Sentience, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Trevarthen, A. C., Resasco, A., Finnegan, E. M. et al. 2024. An exploration of the postural, location- and social contact- related sub-characteristics of inactive but awake behaviour as a depression-like indicator in mice. Applied Animal Behaviour Science 281, 106431.

Rattling the cage: Behaviour and resource use of mice in laboratory and pet cages

Conventional housing for laboratory mice limits the expression of species-specific behaviours and restricts the control over their environment, thus failing to guarantee the animals' welfare. To better understand the behaviour and resource use of laboratory mice, we housed mice (n...

Year Published: 2024Topics: Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Gygax, M., Fortes, M. S., Voelkl, B. et al. 2024. Rattling the cage: Behaviour and resource use of mice in laboratory and pet cages. Applied Animal Behaviour Science 278, 106381.

The implementation of tunnel handling in a mouse breeding facility revealed strain-specific behavioural responses

As a step towards implementing non-aversive handling techniques at a big mouse breeding facility in Germany, tunnel handling was introduced in a breeding unit comprising three inbred mouse strains. To assess whether tunnel handling would be feasible for the animal...

Year Published: 2024Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Hohlbaum, K., Merle, R., Warnke, R. et al. 2024. The implementation of tunnel handling in a mouse breeding facility revealed strain-specific behavioural responses. Laboratory Animals 58(6), 552–564.

Refining urine collection in mice: Development of an innovative urine collection device

Urine collection can be challenging in studies involving small rodents like mice, as the actual methods of collection are anxiogenic and constrain animal welfare while having high variability in the volume of urine collected. To improve the current methods and...

Year Published: 2024Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Douté, M., Monzali, C., Nicoletti, A. et al. 2024. Refining urine collection in mice: Development of an innovative urine collection device. Laboratory Animals 58(6), 612–615.

Elevating the welfare of mouse dams: A pilot study on elevated tunnels for breeding mice

Mouse dams and their pups may benefit from more gradual weaning, but this is not possible in standard laboratory cages because dams cannot physically separate from their pups. Allowing mouse dams to control nursing may improve their welfare and encourage...

Year Published: 2024Topics: Rearing & WeaningAnimal Type: Mouse, Rodent

Citation: Ratuski, A. S., Makowska, I. J., Weary, D. M., 2024. Elevating the welfare of mouse dams: A pilot study on elevated tunnels for breeding mice. Laboratory Animal Science Professional 12(5) (September/October), 52–55.

The extent and function of ‘food grinding’ in the laboratory mouse (Mus musculus)

Many laboratory rodents grind their food into crumbs that are discarded at the bottom of the cage (sometimes called orts). This can have substantial impacts on measures of food intake and assimilation efficiency. We quantified food grinding in two laboratory...

Year Published: 2010Topics: Abnormal/Problematic BehaviorAnimal Type: Mouse, Rodent

Citation: Cameron, K. M., Speakman, J. R. 2010. The extent and function of ‘food grinding' in the laboratory mouse (Mus musculus). Laboratory Animals 44(4), 298-304.

Effect of ground transportation on adrenocortical activity in prepuberal female mice from five different genetic backgrounds

Specific experimental protocols necessitate transportation, a potentially stressful event that could confound results. We determined adrenocortical activity by measuring fecal corticosterone metabolites (FCMs), as a stress marker, in prepuberal (three-week old) female C57BL/6J, C57BL/6NCrl, FVB/NCrl, Crl:CD1(ICR), and BALB/cAnCrl mice. On...

Year Published: 2019Topics: Relocation & TransportAnimal Type: Mouse, Rodent

Citation: Rumpel, S., Scholl, C., Göbel, A. et al. 2019. Effect of ground transportation on adrenocortical activity in prepuberal female mice from five different genetic backgrounds. Animals 9(5), 239.