Mouse

Strain differences in temporal changes of nesting behaviors in C57BL/6N, DBA/2N, and their F1 hybrid mice assessed by a three-dimensional monitoring system

Nest building is one of the innate behaviors that are widely observed throughout the animal kingdom. Previous studies have reported specific brain regions and genetic loci associated with nest building in mice. These studies mainly evaluated the nest structure, without...

Year Published: 2015Topics: Environmental Enrichment, Natural BehaviorAnimal Type: Mouse, Rodent

Citation: Goto, T., Okayama, T., Toyoda, A. 2015. Strain differences in temporal changes of nesting behaviors in C57BL/6N, DBA/2N, and their F1 hybrid mice assessed by a three-dimensional monitoring system. Behavioural Processes 119, 86-92.

Using dried blood spot sampling to improve data quality and reduce animal use in mouse pharmacokinetic studies

Traditional pharmacokinetic analysis in nonclinical studies is based on the concentration of a test compound in plasma and requires approximately 100 to 200 μL blood collected per time point. However, the total blood volume of mice limits the number of...

Year Published: 2015Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Wickremsinhe, E. R., Perkins, E. J. 2015. Using dried blood spot sampling to improve data quality and reduce animal use in mouse pharmacokinetic studies. JAALAS. 54(2), 139-144.

Miniaturized blood sampling techniques to benefit reduction in mice and refinement in nonhuman primates: Application to bioanalysis in toxicity studies with antibody-drug conjugates

Minimizing the number of animals in regulatory toxicity studies while achieving study objectives to support the development of future medicines contributes to good scientific and ethical practices. Recent advances in technology have enabled the development of miniaturized blood sampling methods...

Year Published: 2015Topics: Biological Sampling & Physiological MeasurementAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Mouse, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Rodent, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Caron, A., Lelong, C., Pascual, M. H. et al. 2015. Miniaturized blood sampling techniques to benefit reduction in mice and refinement in nonhuman primates: Application to bioanalysis in toxicity studies with antibody-drug conjugates. JAALAS 54(2), 145-152.

Characteristics of vibration that alter cardiovascular parameters in mice

We hypothesized that short-term exposure of mice to vibration within a frequency range thought to be near the resonant frequency range of mouse tissue and at an acceleration of 0 to 1 m/s2 would alter heart rate (HR) and mean...

Year Published: 2015Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Li, Y., Rabey, K. N., Schmitt, D. et al. 2015. Characteristics of vibration that alter cardiovascular parameters in mice. JAALAS 54(4), 372-377.

Using the mouse grimace scale to assess pain associated with routine ear notching and the effect of analgesia in laboratory mice

Social housing is recommended where possible for laboratory mice. In order to achieve this, mice must be individually identifiable. Although, various methods are available, permanent identification is often required, such as ear notching. This method is likely to be painful...

Year Published: 2015Topics: Analgesia, Identification MethodAnimal Type: Mouse, Rodent

Citation: Miller, A. L., Leach, M. C. 2015. Using the mouse grimace scale to assess pain associated with routine ear notching and the effect of analgesia in laboratory mice. Laboratory Animals 49(2), 117-120.

Assessing the welfare of laboratory mice in their home environment using animal-based measures – a benchmarking tool

Welfare problems in laboratory mice can be a consequence of an ongoing experiment, or a characteristic of a particular genetic line, but in some cases, such as breeding animals, they are most likely to be a result of the design...

Year Published: 2016Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Spangenberg, E. M. F., Keeling, L. J. 2016. Assessing the welfare of laboratory mice in their home environment using animal-based measures - a benchmarking tool. Laboratory Animals 50(1), 30-38.

The effects of group and single housing and automated animal monitoring on urinary corticosterone levels in male C57Bl/6 mice

Mice are used extensively in physiological research. Automated home‐cage systems have been developed to study single‐housed animals. Increased stress by different housing conditions might affect greatly the results when investigating metabolic responses. Urinary corticosteroid concentration is considered as a stress...

Year Published: 2016Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Kamakura, R., Kovalainen, M., Leppaluoto. J. et al. 2016. The effects of group and single housing and automated animal monitoring on urinary corticosterone levels in male C57Bl/6 mice. Physiological Reports 4(3), e12703.

Effects of stereotypic behaviour and chronic mild stress on judgement bias in laboratory mice

Cognitive processes are influenced by underlying affective states, and tests of cognitive bias have recently been developed to assess the valence of affective states in animals. These tests are based on the fact that individuals in a negative affective state...

Year Published: 2016Topics: Abnormal/Problematic Behavior, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Novak, J., Stojanovski, K., Melotti, L. et al. 2016. Effects of stereotypic behaviour and chronic mild stress on judgement bias in laboratory mice. Applied Animal Behaviour Science 174, 162-172.

Effects of type of light on mouse circadian behaviour and stress levels

Light is the principal synchronizing environmental factor for the biological clock. Light quantity (intensity), and light quality (type of light source) can have different effects. The aim of this study was to determine the effects of the type of light...

Year Published: 2016Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Alves-Simoes, M., Coleman, G., Canal, M. M. 2016. Effects of type of light on mouse circadian behaviour and stress levels. Laboratory Animals 50(1), 21-29.