Mouse

Pharmacokinetic evaluation of a topical extended-release analgesic in mice

Mice often undergo painful procedures and surgeries as part of biomedical research protocols. Buprenorphine, a partial μ-opioid receptor agonist and κ receptor antagonist, is commonly used to alleviate the pain associated with such procedures. Due to its pharmacokinetic profile, buprenorphine...

Year Published: 2024Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Simmons, T., Hish, G., Martin, T. L. et al. 2024. Pharmacokinetic evaluation of a topical extended-release analgesic in mice. JAALAS 63(5), 581–586.

Voluntary wheel running as an effective intervention in the management of excessive food usage in CD-1 mice (Mus musculus)

Some mice demonstrate excessive food-grinding behaviors in which food pellets are broken down into crumbs (orts). This is considered abnormal behavior and is undesirable in a research environment, as it is thought to potentially be a stereotypic behavior suggestive of...

Year Published: 2024Topics: Abnormal/Problematic BehaviorAnimal Type: Mouse, Rodent

Citation: Skurnack, A. M. E., Lane, S. P., Garman, L. et al. 2024. Voluntary wheel running as an effective intervention in the management of excessive food usage in CD-1 mice (Mus musculus). JAALAS 63(5), 504–512.

Refined tamoxifen administration in mice by encouraging voluntary consumption of palatable formulations

Drug administration in preclinical rodent models is essential for research and the development of novel therapies. Compassionate administration methods have been developed, but these are mostly incompatible with water-insoluble drugs such as tamoxifen or do not allow for precise timing...

Year Published: 2024Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Vanhecke, D., Bugada, V., Steiner, R. et al. 2024. Refined tamoxifen administration in mice by encouraging voluntary consumption of palatable formulations. Lab Animal 53(8), 205–214.

Effects of supplemental diet during breeding on fertility, litter size, survival rate, and weaning weight in mice (Mus musculus)

The addition of supplemental diets to laboratory animals, specifically rodents, is a common practice for the provision of additional nutritional support. We set out to investigate whether the use of commercially available supplemental diets during breeding affected fertility rate, litter...

Year Published: 2024Topics: Rearing & Weaning, ReproductionAnimal Type: Mouse, Rodent

Citation: Wong, R. K., Carriero, S. J., Wadsworth, B. C. et al. 2024. Effects of supplemental diet during breeding on fertility, litter size, survival rate, and weaning weight in mice (Mus musculus). JAALAS 63(5), 480–487.

Effects of nesting material and housing parameters on feed wastage behavior in female Swiss Webster mice

Feed wastage in laboratory mice, also known as chewing or grinding behavior, is problematic for program management and animal welfare. The destruction of pelleted feed without consumption produces a powder accumulation on the cage floor called orts. Ort accumulation disrupts...

Year Published: 2024Topics: Abnormal/Problematic BehaviorAnimal Type: Mouse, Rodent

Citation: Zawacki, Z. E., Sharpe, J. A., Porco, T. C. et al. 2024. Effects of nesting material and housing parameters on feed wastage behavior in female Swiss Webster mice. JAALAS 63(5), 495–503.

Effects of temporary access to environmental enrichment on measures of laboratory mouse welfare

Laboratory mice are typically housed in “shoebox” cages with limited opportunities to engage in natural behaviour. Temporary access to environments with increased space and complexity (playpens) may improve mouse welfare. Previous work by our group has shown that mice are...

Year Published: 2024Topics: Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Ratuski, A. S., Améndola, L., Makowska, I. J. et al. 2024. Effects of temporary access to environmental enrichment on measures of laboratory mouse welfare. Scientific Reports 14(1), 15143.

Effects of intermittent harem mating on parturition-induced stress and success rate of weaning in C57BL/6JNarl mice

Improving the effectiveness of mating schemes for large-scale production of mice is an ongoing challenge in animal facilities. Continuous mating, which requires fewer breeding cages than intermittent mating, has traditionally been used to take advantage of postpartum estrus for efficient...

Year Published: 2024Topics: Rearing & Weaning, ReproductionAnimal Type: Mouse, Rodent

Citation: Chang, T.-K., Wang, C.-H., Lin, T.-Y. et al. 2024. Effects of intermittent harem mating on parturition-induced stress and success rate of weaning in C57BL/6JNarl mice. JAALAS 63(5), 488–494.

Noise and vibration generation and response of mice (Mus musculus) to routine intrafacility transportation methods

Intrafacility transport of mice is an essential function for both laboratory and husbandry personnel. However, transport may induce a stress response that can alter research findings and negatively impact animal welfare. To determine minimally adverse intrafacility transport methods, in-cage noise...

Year Published: 2024Topics: Relocation & TransportAnimal Type: Mouse, Rodent

Citation: Cordingley, J. R., Nemzek, J., Qi, N. 2024. Noise and vibration generation and response of mice (Mus musculus) to routine intrafacility transportation methods. JAALAS 63(3), 221–231.

Guidance on the transport of laboratory animals

Report of the Transport Working Group established by the Laboratory Animal Science Association (LASA)

Year Published: 2005Topics: Relocation & TransportAnimal Type: Amphibian, Cat, Dog, Ferret, Frog & Toad, Guinea Pig, Hamster, Macaque, Marmoset, Mouse, Nonhuman Primate, Pig, Rabbit, Rat, Rodent, Salamander

Citation: Swallow, J., Anderson, D., Buckwell, A. C. et al. 2005. Guidance on the transport of laboratory animals. Laboratory Animals 39(1), 1-39.

Cage-induced stereotypies in female ICR CD-1 mice do not correlate with recurrent perseveration

Stereotypies are repetitive, unvarying, apparently purposeless behavioural patterns. They develop in animals kept in barren environments and are highly prevalent in laboratory mice (Mus musculus), yet their underlying mechanisms have remained elusive. In humans, stereotypies are associated with several psychiatric...

Year Published: 2011Topics: Abnormal/Problematic Behavior, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Gross, A. N., Engel, A. K. J., Richter, S. H. et al. 2011. Cage-induced stereotypies in female ICR CD-1 mice do not correlate with recurrent perseveration. Behavioural Brain Research 216(2), 613-620.