Dog

Refining procedures within regulatory toxicology studies: Improving animal welfare and data

During the development of potential new medicines or agrochemicals, an assessment of the safety profile to humans and environmental species is conducted using a range of different in silico and in vitro techniques in conjunction with metabolism and toxicity studies...

Year Published: 2021Topics: Biological Sampling & Physiological Measurement, Cannulation, Catheterization, & Intubation, HousingAnimal Type: Dog, Fish, Mouse, Nonhuman Primate, Pig, Rabbit, Rat, Rodent

Citation: Prior, H., Blunt, H., Crossman, L. et al. 2021. Refining procedures within regulatory toxicology studies: Improving animal welfare and data. Animals 11(11), 3057.

Effect of an insulation device in preventing hypothermia during magnetic resonance imaging examinations for dogs and cats under general anesthesia

Dogs and cats under general anesthesia may develop hypothermia. When performing a magnetic resonance imaging (MRI) examination, it is not possible to place a magnetic material in the MRI room, and MRI equipment requires a low room temperature. This study...

Year Published: 2021Topics: Imaging & Electrophysiological RecordingAnimal Type: Cat, Dog

Citation: Onozawa, E., Azakami, D., Seki, S. et al. 2021. Effect of an insulation device in preventing hypothermia during magnetic resonance imaging examinations for dogs and cats under general anesthesia. Animals 11(8), 2378.

Comparison of pain response after subcutaneous injection of two maropitant formulations to beagle dogs

The antiemetic maropitant, with metacresol as preservative (Cerenia, Zoetis), has been associated with pain after subcutaneous injection in dogs and cats. Recently, a generic formulation containing benzyl alcohol was authorised (Prevomax, Le Vet). Benzyl alcohol is reported to have local...

Year Published: 2018Topics: Drug/Substance AdministrationAnimal Type: Dog

Citation: Deckers, N., Ruigrok, C. A., Verhoeve, H. P. et al. 2018. Comparison of pain response after subcutaneous injection of two maropitant formulations to beagle dogs. Veterinary Record Open 5(1), e000262.

Evaluating pair versus solitary housing in kennelled domestic dogs (Canis familiaris) using behaviour and hair cortisol: A pilot study

Numerous studies conducted to assess welfare of domestic dogs housed in kennel facilities have reported that these dogs experience suboptimal living conditions. One important goal of improving welfare of kennelled dogs is to reduce their stress levels, and one recommended...

Year Published: 2017Topics: Social Housing & CompanionshipAnimal Type: Dog

Citation: Grigg, E.K., Nibblett, B.M., Robinson, J.Q. et al. 2017. Evaluating pair versus solitary housing in kennelled domestic dogs (Canis familiaris) using behaviour and hair cortisol: A pilot study. Veterinary Record Open 4(1), e000193.

Influence of dog appeasing pheromone (DAP) on dogs housed in a long-term kennelling facility

Introduction: Kennel facilities are commonly acknowledged as a stressful environment for many domestic dogs (Canis familiaris). One therapeutic measure used to reduce anxiety in dogs is dog appeasing pheromone (DAP), which has been found effective in reducing stress-related behaviours in...

Year Published: 2015Topics: Husbandry & ManagementAnimal Type: Dog

Citation: Grigg, E.K., Piehler, M. 2015. Influence of dog appeasing pheromone (DAP) on dogs housed in a long-term kennelling facility. Veterinary Record Open 2(1), e000098.

DIY: Dehydrated watermelon training chips

This simple DIY training treat is great for NHP, swine, rabbits, rodents, and dogs. Note that dehydrated watermelon may resemble muscle tissue!

Year Published: 2021Topics: Environmental EnrichmentAnimal Type: Baboon, Capuchin, Chimpanzee, Chinchilla, Dog, Gerbil, Guinea Pig, Hamster, Lemur, Macaque, Marmoset, Mouse, Nonhuman Primate, Other Nonhuman Primate, Other Rodent, Owl Monkey, Pig, Rabbit, Rat, Rodent, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Lambert, K. 2021. DIY: Dehydrated watermelon training chips. Laboratory Animal Science Professional 9(4) (July/August), 48.

Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

Introduction: A successful integration of automated blood sampling (ABS) into the telemetry instrumented canine cardiovascular model is presented in this study. This combined model provides an efficient means to quickly gain understanding of potential effects on key cardiovascular parameters in...

Year Published: 2021Topics: Biological Sampling & Physiological MeasurementAnimal Type: Dog

Citation: Koshman, Y. E., Wilsey, A. S., Bird, B. M. et al. 2021. Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins. Journal of Pharmacological and Toxicological Methods 109, 107066.

Refining dosing by oral gavage in the dog: A protocol to harmonise welfare

Introduction: The dog is a frequently-used, non-rodent species in the safety assessment of new chemical entities. We have a scientific and ethical obligation to ensure that the best quality of data is achieved from their use. Oral gavage is a...

Year Published: 2015Topics: Drug/Substance AdministrationAnimal Type: Dog

Citation: Hall, L. E., Robinson, S., Buchanan-Smith, H. E. 2015. Refining dosing by oral gavage in the dog: A protocol to harmonise welfare. Journal of Pharmacological and Toxicological Methods 72, 35-46.

Reducing suffering in experimental autoimmune encephalomyelitis (EAE)

This report is based on discussions and submissions from an expert working group consisting of veterinarians, animal care staff and scientists with expert knowledge relevant to the field. It aims to facilitate the implementation of the Three Rs (replacement, reduction...

Year Published: 2013Topics: Disease/Experimental ModelAnimal Type: Dog, Guinea Pig, Hamster, Macaque, Marmoset, Mouse, Nonhuman Primate, Rabbit, Rat, Rodent, Sheep

Citation: Wolfensohn, S., Hawkins, P., Lilley, E. et al. 2013. Reducing suffering in experimental autoimmune encephalomyelitis (EAE). Journal of Pharmacological and Toxicological Methods 67(3), 169-176.

The effects of housing conditions on baseline cardiovascular parameters and the sensitivity to detect changes in contractility in telemetry-implanted dogs

Introduction: There is a growing weight of evidence to suggest that myocardial contractility is an important parameter to assess as part of IND enabling studies in addition to standard assessments as per the ICH S7A and S7B guidelines. Historically, assessments...

Year Published: 2016Topics: Biological Sampling & Physiological Measurement, External Bodily Equipment, Social Housing & CompanionshipAnimal Type: Dog

Citation: Sadekova, N., Boudreau, G., Jalbert, B. et al. 2016. The effects of housing conditions on baseline cardiovascular parameters and the sensitivity to detect changes in contractility in telemetry-implanted dogs. Journal of Pharmacological and Toxicological Methods 81, 60-74.