All/General

Validation of a 3D perfused cell culture platform as a tool for humanised preclinical drug testing in breast cancer using established cell lines and patient-derived tissues

3D cell culture models of cancer are currently being developed to recapitulate in vivo physiological conditions and to assess therapeutic responses. However, most models failed to incorporate the biochemical and biophysical stimuli from fluid flow. In this study, a three-dimensional...

Year Published: 2023Topics: Disease/Experimental ModelAnimal Type: All/General

Citation: Liu, P., Roberts, S., Shoemaker, J. T. et al. 2023. Validation of a 3D perfused cell culture platform as a tool for humanised preclinical drug testing in breast cancer using established cell lines and patient-derived tissues. PLOS ONE 18(3), e0283044.

A model framework for the estimation of animal “suffering”: Its use in predicting and retrospectively assessing the impact of experiments on animals

This paper presents and illustrates, with a working example, a hypothesis for the assessment of ongoing severity before and during an experiment that will enable humane endpoints and intervention points to be applied accurately and reproducibly, as well as helping...

Year Published: 2023Topics: Humane Endpoint, Welfare AssessmentAnimal Type: All/General

Citation: Morton, D. B. 2023. A model framework for the estimation of animal “suffering”: Its use in predicting and retrospectively assessing the impact of experiments on animals. Animals 13(5), 800.

A new strategy for animal research: Attending to dissent

Increasingly, ethical concepts ordinarily reserved for the human research setting have been applied to nonhuman animals in research. This comes at the same time as concerns mount over challenges in translating the results of biomedical research with animals to human...

Year Published: 2023Topics: Animal Training, Regulations & Ethical ReviewAnimal Type: All/General

Citation: Johnson, J. 2023. A new strategy for animal research: Attending to dissent. Animals 13(9), 1491.

Effects of castration and sterilization on baseline and response levels of cortisol—A case study in male guinea pigs

An uncontrolled reproduction of animals in human hands should be avoided. To meet this goal, animals are widely castrated, i.e., the gonads are completely removed. Since the gonads are the most important source of sex hormones, this is a serious...

Year Published: 2023Topics: Body Modification/Mutilation, ReproductionAnimal Type: All/General, Guinea Pig, Rodent

Citation: Kaiser, S., Korte, A., Wistuba, J. et al. 2023. Effects of castration and sterilization on baseline and response levels of cortisol—A case study in male guinea pigs. Frontiers in Veterinary Science 9, 1093157.

Animal welfare considerations when conducting OECD test guideline inhalation and toxicokinetic studies for nanomaterials

The OECD test guidelines for animal experiments play an important role in evaluating the chemical hazards. Animal tests performed using OECD guidelines, especially when the good laboratory practice (GLP) principle is applied, reduce the duplication of toxicity testing and ensure...

Year Published: 2022Topics: Disease/Experimental ModelAnimal Type: All/General, Rat, Rodent

Citation: Chung, Y. H., Gulumian, M., Pleus, R. C. et al. 2022. Animal welfare considerations when conducting OECD test guideline inhalation and toxicokinetic studies for nanomaterials. Animals 12(23), 3305.

Designing animal-friendly behavioral tests for neuroscience research: The importance of an ethological approach

Behavioral tests have three key elements: (1) a motivating factor (what motivates the animal in the test); (2) an observable behavior (which behaviors we may expect the animal exhibits in response to the test); (3) a measurable outcome (a quantifiable...

Year Published: 2023Topics: Behavioral & Cognitive TestingAnimal Type: All/General

Citation: d'Isa, R., Gerlai, R. 2023. Designing animal-friendly behavioral tests for neuroscience research: The importance of an ethological approach. Frontiers in Behavioral Neuroscience 16, 1090248.

Investigating attentional scope as a novel indicator of emotional state in animals

In humans, contrasting emotional states can lead to a broadening or narrowing of attentional scope. Whether this is also the case in animals has yet to be investigated. If confirmed, measurement of attentional scope has potential as a novel cognitive...

Year Published: 2022Topics: Welfare AssessmentAnimal Type: All/General, Dog

Citation: Hamlaoui, A., Keeling, L., Burman, O. et al. 2022. Investigating attentional scope as a novel indicator of emotional state in animals. Scientific Reports 12(1), 17452.

Humane Intervention Points: Refining endpoint terminology to incorporate non-euthanasia intervention options to improve animal welfare and preserve experimental outcomes

Consideration of The Three R's (Replacement, Reduction, and Refinement) is essential when setting Humane Endpoints; however, a common interpretation assumes that Humane Endpoints are timepoints to perform euthanasia. This interpretation is not always consistent with the three Rs. There are...

Year Published: 2022Topics: Humane EndpointAnimal Type: All/General

Citation: Williams, W. O., Baneux, P. 2022. Humane Intervention Points: Refining endpoint terminology to incorporate non-euthanasia intervention options to improve animal welfare and preserve experimental outcomes. Laboratory Animals 56(5), 482-489.

Integrative Model of Human-Animal Interactions: A One Health–One Welfare systemic approach to studying HAI

The Integrative Model of Human-Animal Interactions (IMHAI) described herewith provides a conceptual framework for the study of interspecies interactions and aims to model the primary emotional processes involved in human-animal interactions. This model was developed from theoretical inputs from three...

Year Published: 2022Topics: Human-Animal InteractionAnimal Type: All/General

Citation: Leconstant, C., Spitz, E. 2022. Integrative Model of Human-Animal Interactions: A One Health–One Welfare systemic approach to studying HAI. Frontiers in Veterinary Science 9, 656833.

Music for animal welfare: A critical review & conceptual framework

Music can have powerful effects on human health and wellbeing. These findings have inspired an emerging field of research that focuses on the potential of music for animal welfare, with most studies investigating whether music can enhance overall wellbeing. However,...

Year Published: 2022Topics: Environmental EnrichmentAnimal Type: All/General

Citation: Kriengwatana, B. P., Mott, R., ten Cate, C. 2022. Music for animal welfare: A critical review & conceptual framework. Applied Animal Behaviour Science 251, 105641.