Handling

The impact of handling technique and handling frequency on laboratory mouse welfare is sex-specific

Handling is a well-known source of stress to laboratory animals and can affect variability of results and even compromise animal welfare. The conventional tail handling in mice has been shown to induce aversion and anxiety-like behaviour. Recent findings demonstrate that...

Year Published: 2020Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Sensini, F., Inta, D., Palme, R. et al. 2020. The impact of handling technique and handling frequency on laboratory mouse welfare is sex-specific. Scientific Reports 10(1), 17281.

Report of the 2019 RSPCA/UFAW Rodent Welfare meeting

The RSPCA/UFAW Rodent Welfare Group has held a one-day meeting every autumn for the last 26 years, so that its members can discuss current welfare research, exchange views on welfare issues, and share experiences of the implementation of the 3Rs...

Year Published: 2020Topics: Animal Training, Environmental Enrichment, Handling, Housing, Husbandry & Management, Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: Stevens, C., Finnegan, E., Clarkson, J. et al. 2020. Report of the 2019 RSPCA/UFAW Rodent Welfare meeting. Animal Technology and Welfare 19(2), 101-111.

Assessment of hematologic and corticosterone response in free-living eastern box turtles (Terrapene carolina carolina) at capture and after handling

Hematology is a common tool for wildlife health assessments. Manual leukocyte counts are required in reptiles, however, disagreement between quantification methods has been observed in some chelonians. This study determined agreement between two methods of leukocyte quantification, eosinophilic leukopet, and...

Year Published: 2020Topics: Biological Sampling & Physiological Measurement, HandlingAnimal Type: Reptile, Turtle & Tortoise

Citation: Boers, K. L., Allender, M. C., Novak, L. J. et al. 2020. Assessment of hematologic and corticosterone response in free-living eastern box turtles (Terrapene carolina carolina) at capture and after handling. Zoo Biology 39(1), 13-22.

Benefits of tunnel handling persist after repeated restraint, injection and anaesthesia

Millions of mice are used every year for scientific research, representing the majority of scientific procedures conducted on animals. The standard method used to pick up laboratory mice for general husbandry and experimental procedures is known as tail handling and...

Year Published: 2020Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Henderson, L. J., Dani, B., Serrano, E. M. N., et al. 2020. Benefits of tunnel handling persist after repeated restraint, injection and anaesthesia. Scientific Reports 10(1), 14562.

Effects of repetitive gentle handling of male C57BL/6NCrl mice on comparative behavioural test results

Mice are the most commonly used laboratory animals for studying diseases, behaviour, and pharmacology. Behavioural experiment battery aids in evaluating abnormal behaviour in mice. During behavioural experiments, mice frequently experience human contact. However, the effects of repeated handling on mice...

Year Published: 2020Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Ueno, H., Takahashi, Y., Suemitsu, S. et al. 2020. Effects of repetitive gentle handling of male C57BL/6NCrl mice on comparative behavioural test results. Scientific Reports 10(1), 3509.

Identifying obstacles preventing the uptake of tunnel handling methods for laboratory mice: An international thematic survey

Handling of laboratory mice is essential for experiments and husbandry, but handling can increase anxiety in mice, compromising their welfare and potentially reducing replicability between studies. The use of non-aversive handling (e.g., tunnel handling or cupping), rather than the standard...

Year Published: 2020Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Henderson, L. J., Smulders, T. V., Roughan, J. V. 2020. Identifying obstacles preventing the uptake of tunnel handling methods for laboratory mice: An international thematic survey. PLOS ONE 15(4), e0231454.

Getting a grip: Cats respond negatively to scruffing and clips

Use of scruffing and scruffing tools (eg, clipnosis clips) to immobilise cats is contentious, and cat handling guidelines vary in recommendations regarding these techniques. The current study examined whether cats show negative responses to the following restraint methods: (1) scruff...

Year Published: 2020Topics: Handling, RestraintAnimal Type: Cat

Citation: Moody, C. M., Mason, G. J., Dewey, C. E. et al. 2020. Getting a grip: Cats respond negatively to scruffing and clips. Veterinary Record 186(12), 385.

Now hear this: Caring for chinchillas in research

This article describes the authors’ experience with the housing, social housing, husbandry, handling, and environmental enrichment of chinchillas in laboratories.

Year Published: 2020Topics: Environmental Enrichment, Handling, Housing, Husbandry & ManagementAnimal Type: Chinchilla

Citation: LaFleur, R. A., Williams-Fritze, M. J. 2020. Now hear this: Caring for chinchillas in research. Laboratory Animal Science Professional 8(5) (September/October), 8-12.

Managed care of naked mole-rats

Naked mole-rats are a burgeoning model species in the field of biomedical research and are also housed at many zoos throughout the world. These mammals possess many traits that have a large impact on the way that they are kept...

Year Published: 2021Topics: Biological Sampling & Physiological Measurement, Environmental Enrichment, Handling, Housing, Husbandry & Management, Identification Method, Rearing & Weaning, Relocation & Transport, Reproduction, Restraint, Social Housing & CompanionshipAnimal Type: Mole Rat, Rodent

Citation: Smith, M., Buffenstein, R. 2021. Managed care of naked mole-rats. In: R. Buffenstein, T. J. Park, M. M. Holmes (Eds.), The Extraordinary Biology of the Naked Mole-Rat. Springer International Publishing, pp. 381–407.

Non-aversive handling in laboratory animals and its effects on depressive-like and anxiety-related behaviors: A scoping review

Stress is an adaptive response to environmental demands, but increased intensity and frequency can lead to impaired adaptive functions. Stress is considered a risk factor for Major Depressive Disorder, a multifactorial disorder that often coexists with anxiety. Picking up laboratory...

Year Published: 2025Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Castro de Jesus, L., S․ Rodrigues, A. L. 2025. Non-aversive handling in laboratory animals and its effects on depressive-like and anxiety-related behaviors: A scoping review. Physiology & Behavior 294, 114883.