Disease/Experimental Model

Refinement in post-surgical recovery

Pre- and post-surgical care includes providing the animals with a soft version of their standard Irradiated diet. Food pellets are soaked in sterile water and this turns into a mash. This ensures that the animals are well hydrated prior to...

Year Published: 2016Topics: Disease/Experimental Model, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Robertson, A. 2016. Refinement in post-surgical recovery. Animal Technology and Welfare 15(1), 62-63.

Report of the 2016 RSPCA/UFAW Rodent and Rabbit Welfare Group meeting

The RSPCA/UFAW Rodent (and now Rabbit) Welfare Group held a one-day meeting on 1 November 2016 at the University of Edinburgh and was attended by 70 delegates. Presentation topics included refinements in blood sampling rodents, reducing suffering in projects involving...

Year Published: 2017Topics: Biological Sampling & Physiological Measurement, Disease/Experimental Model, Husbandry & Management, Welfare AssessmentAnimal Type: Mouse, Rabbit, Rat, Rodent

Citation: Hawkins, P., McNeilly, A., Watson, J. et al. 2017. Report of the 2016 RSPCA/UFAW Rodent and Rabbit Welfare Group meeting. Animal Technology and Welfare 16(2), 77-86.

Refinement of perioperative feeding in a mouse model of vertical sleeve gastrectomy

Provision of liquid enteral nutrition (LEN) during the perioperative period is standard practice for rodents undergoing bariatric surgery, yet these diets are associated with several challenges, including coagulation of the liquid diet within the delivery system and decreased postoperative consumption....

Year Published: 2018Topics: Disease/Experimental Model, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Doerning, C. M., Burlingame, L. A., Lewis, A. G. et al. 2018. Refinement of perioperative feeding in a mouse model of vertical sleeve gastrectomy. JAALAS 57(3), 295-301.

Experimental control for the ovariectomized rat model: Use of sham versus nonmanipulated animal

One of 2 models required by the U.S. Food and Drug Administration for registration of a treatment for osteoporosis, the ovariectomized (OVX) rat model, is widely used in scientific studies investigating sex hormone-deficient bone loss. The use of control nonhuman...

Year Published: 2016Topics: Disease/Experimental Model, ReproductionAnimal Type: Rat, Rodent

Citation: Kruger, M. C., Morel, P. C. H. 2016. Experimental control for the ovariectomized rat model: Use of sham versus nonmanipulated animal. Journal of Applied Animal Welfare Science 19(1), 73-80.

TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding

Transgenic tumour necrosis factor alpha (TNFα)-driven models of polyarthritis such as the TNFΔARE mouse have proven to be invaluable in delineating aspects of inflammatory disease pathophysiology in humans. Unfortunately, the onset of joint destruction and inflammation in these models represents...

Year Published: 2018Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Naylor, A. J., Desanti, G., Saghir, A. N. et al. 2018. TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding. Laboratory Animals 52(1), 59-68.

A refined and translationally relevant model of chronic DSS colitis in BALB/c mice

Inflammatory bowel diseases (IBD) are chronic relapsing disorders of the gastrointestinal tract. Several mouse models for IBD are available, but the acute dextran sulfate sodium (DSS)-induced colitis model is mostly used for preclinical studies. However, this model lacks chronicity and...

Year Published: 2018Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Hoffmann, M., Schwertassek, U., Seydel, A. et al. 2018. A refined and translationally relevant model of chronic DSS colitis in BALB/c mice. Laboratory Animals 52(3), 240-252.

Ethical principles for the maintenance and use of animal in neuroscience research

Maintenance of experimental animals should account for species-specific needs of accommodation, activity, feeding and social interactions to the degree possible [p. 1].

Year Published: 1987Topics: Disease/Experimental ModelAnimal Type: All/General

Citation: Zimmermann, M. 1987. Ethical principles for the maintenance and use of animal in neuroscience research. Neuroscience Letters 73, 1.

Chimpanzees in AIDS research: A biomedical and bioethical perspective

The present article represents a consensus view of the appropriate utilization of chimpanzees in AIDS research arrived at as a result of a meeting of a group of scientists involved in AIDS research with chimpanzees and bioethicists. The paper considers...

Year Published: 1994Topics: Disease/Experimental Model, Relocation & Transport, Social Housing & CompanionshipAnimal Type: Chimpanzee, Nonhuman Primate

Citation: van Akker, R., Balls, M., Eichberg, J. W. et al. 1994. Chimpanzees in AIDS research: A biomedical and bioethical perspective. Journal of Medical Primatology 23, 49-51.

The Boyd Group of papers on: The use of non-human primates in research and testing – Pager 1: Background information on the use of non-human primates

Number of non-human primates used in scientific procedures in Britain in 2000: New World monkeys [marmosets, tamarins] 1060; Old World monkeys [macaques] 1891 [p.100].

Year Published: 2003Topics: Disease/Experimental ModelAnimal Type: Nonhuman Primate, Salamander

Citation: Smith, J. A., Boyd, K. M. e. 2003. The Boyd Group of papers on: The use of non-human primates in research and testing - Pager 1: Background information on the use of non-human primates. Animal Technology and Welfare 2, 99-103.

The poor contribution of chimpanzee experiments to biomedical progress

Biomedical research on captive chimpanzees incurs substantial nonhuman animal welfare, ethical, and financial costs that advocates claim result in substantial advancements in biomedical knowledge. However, demonstrating minimal contribution toward the advancement of biomedical knowledge generally, subsequent papers did not cite...

Year Published: 2007Topics: Disease/Experimental Model, Regulations & Ethical ReviewAnimal Type: Chimpanzee, Nonhuman Primate

Citation: Knight, A. 2007. The poor contribution of chimpanzee experiments to biomedical progress. Journal of Applied Animal Welfare Science 10(4), 281-308.