Biological Sampling & Physiological Measurement

Blood microsampling in cynomolgus monkey and evaluation of plasma PK parameters in comparison to conventional sampling

Microsampling, a reduced volume sampling method, has successfully gained attention at the International Conference on Harmonization (ICH) level and established benefits support its use in Toxicokinetic (TK) studies. These improved sampling techniques are less invasive and in large animal species...

Year Published: 2023Topics: Biological Sampling & Physiological MeasurementAnimal Type: Macaque, Nonhuman Primate

Citation: Bertani, S., Donadi, A., Franchi, J. et al. 2023. Blood microsampling in cynomolgus monkey and evaluation of plasma PK parameters in comparison to conventional sampling. Journal of Pharmacological and Toxicological Methods 123, 107298.

Aced it! Performing large volume survival bleeds in rabbits

New Zealand White rabbits are commonly used for polyclonal antibody production, which can require collecting no more than 10% of total body weight every two weeks (approximately 20 ml of blood for a 4 kg rabbit). In order to collect...

Year Published: 2023Topics: Biological Sampling & Physiological MeasurementAnimal Type: Rabbit

Citation: Brown, A. 2023. Aced it! Performing large volume survival bleeds in rabbits. Laboratory Animal Science Professional 11(3) (May/June), 44-46.

Using a cost-effective, efficient method to train young dogs to cooperate for multiple blood collection procedures in a pharmacokinetics study

Behavioral testing slings, such as the Pavlov sling, offer an effective form of restraint for beagles while minimizing stress. Although these slings provide effective restraint, their high cost makes them less likely to be considered when discussing restraint options, especially...

Year Published: 2023Topics: Animal Training, Biological Sampling & Physiological Measurement, RestraintAnimal Type: Dog

Citation: Rexroat, E. K., Haughton, C. L., Fox, K. 2023. Using a cost-effective, efficient method to train young dogs to cooperate for multiple blood collection procedures in a pharmacokinetics study. Laboratory Animal Science Professional 11(6) (November/December), 34-36.

Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization

Conducting safety evaluations of new drugs using conscious animals has been a specialty of our working group for thirty years. In this article, we review the various technical challenges and solutions dealt with over the years to improve both the...

Year Published: 2023Topics: Biological Sampling & Physiological Measurement, External Bodily EquipmentAnimal Type: Dog, Guinea Pig, Macaque, Mouse, Nonhuman Primate, Pig, Rat, Rodent

Citation: Alizadeh, E. A., Graf, K., Schiwon, J. et al. 2023. Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization. Journal of Pharmacological and Toxicological Methods 122, 107279.

Plasma metabolomics supports non-fasted sampling for metabolic profiling across a spectrum of glucose tolerance in the Nile rat model for type 2 diabetes

Type 2 diabetes is a challenge in modern healthcare, and animal models are necessary to identify underlying mechanisms. The Nile rat (Arvicanthis niloticus) develops diet-induced diabetes rapidly on a conventional rodent chow diet without genetic or chemical manipulation. Unlike common...

Year Published: 2023Topics: Biological Sampling & Physiological Measurement, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Anderson, B. J., Curtis, A. M., Jen, A. et al. 2023. Plasma metabolomics supports non-fasted sampling for metabolic profiling across a spectrum of glucose tolerance in the Nile rat model for type 2 diabetes. Lab Animal 52(11), 269–277.

Social behaviors modulate bottlenose dolphins’ (Tursiops truncatus) breathing rate

Breathing frequency is a non-invasive physiological measure that brings valuable information on the bottlenose dolphins' internal state and behaviors. When combined with behavioral observations, it helps to better understand and interpret relevant behaviors. The present study aimed to investigate some...

Year Published: 2019Topics: Biological Sampling & Physiological Measurement, Welfare AssessmentAnimal Type: Marine Mammal

Citation: Serres, A., Delfour, F. 2019. Social behaviors modulate bottlenose dolphins' (Tursiops truncatus) breathing rate. Animal Behavior and Cognition 6(2), 127–140.

Minimally invasive sampling methods for molecular sexing of wild and companion birds

Birds are highly social and must be paired in order to increase their welfare. Most bird species are monomorphic; therefore, molecular sexing helps provide appropriate welfare for birds. Moreover, early sex determination can be of great value for bird owners....

Year Published: 2023Topics: Biological Sampling & Physiological MeasurementAnimal Type: Bird, Fowl, Other Bird, Parrot

Citation: Turcu, M.-C., Paștiu, A. I., Bel, L.-V. et al. 2023. Minimally invasive sampling methods for molecular sexing of wild and companion birds. Animals 13(21), 3417.

Saliva sampling material matters: Effects on the results of saliva analysis in pigs

The use of saliva as a biological sample from pigs is of high practical interest because blood collection from pigs is difficult and stressful. In this study, the influence of two different materials, a cotton roll and a polypropylene sponge,...

Year Published: 2023Topics: Biological Sampling & Physiological MeasurementAnimal Type: Pig

Citation: Ortín-Bustillo, A., Botía, M., López-Arjona, M. et al. 2023. Saliva sampling material matters: Effects on the results of saliva analysis in pigs. Animals 13(24), 3757.

Non-invasive quantification of faecal and urine reproductive hormone metabolites in the naked mole-rat (Heterocephalus glaber)

The naked mole-rat (Heterocephalus glaber) occurs in colonies with a distinct dominance hierarchy, including one dominant, breeding female (the queen), 1–3 breeding males, and non-reproductive subordinates of both sexes that are reproductively suppressed while in the colony. To non-invasively evaluate...

Year Published: 2023Topics: Biological Sampling & Physiological MeasurementAnimal Type: Rat, Rodent

Citation: Majelantle, T. L., Ganswindt, A., Ganswindt, S. B. et al. 2023. Non-invasive quantification of faecal and urine reproductive hormone metabolites in the naked mole-rat (Heterocephalus glaber). Animals 13(19), 3039.

Non-invasive assessment of the intraventricular pressure using novel color M-mode echocardiography in animal studies: Current status and future perspectives in veterinary medicine

The assessment of diastolic function has received great interest in order to comprehend its crucial role in the pathophysiology of heart failure and for the early identification of cardiac events. Silent changes in the intraventricular flow (IVF) dynamics occur before...

Year Published: 2023Topics: Biological Sampling & Physiological Measurement, Cannulation, Catheterization, & IntubationAnimal Type: All/General

Citation: Mandour, A. S., Farag, A., Helal, M. A. Y. et al. 2023. Non-invasive assessment of the intraventricular pressure using novel color M-mode echocardiography in animal studies: Current status and future perspectives in veterinary medicine. Animals 13(15), 2452.