Anesthesia & Sedation

Sedline® miscalculation of depth of anaesthesia variables in two pigs due to electrocardiographic signal contamination

Two young (11-week-old) pigs underwent sole propofol anaesthesia as part of an experimental study. The depth of anaesthesia was evaluated both clinically and using the electroencephalography(EEG)-based monitor Sedline; in particular, the patient state index, suppression ratio, raw EEG traces, and...

Year Published: 2023Topics: Anesthesia & Sedation, Imaging & Electrophysiological RecordingAnimal Type: Pig

Citation: Mirra, A., Hight, D., Kovacevic, A. et al. 2023. Sedline® miscalculation of depth of anaesthesia variables in two pigs due to electrocardiographic signal contamination. Animals 13(17), 2699.

Determination of a safe sedative combination of dexmedetomidine, ketamine and butorphanol for minor procedures in dogs by use of a stepwise optimization method

In veterinary practice, most minor procedures such as radiographs, skin biopsies, and wound treatments require sedation. The combination of butorphanol, ketamine, and dexmedetomidine is commonly used, but the ideal dosages for this combination have not been defined. This randomized prospective...

Year Published: 2023Topics: Anesthesia & SedationAnimal Type: Dog

Citation: Imboden, T. J., Pownall, W. R., Rubin, S. et al. 2023. Determination of a safe sedative combination of dexmedetomidine, ketamine and butorphanol for minor procedures in dogs by use of a stepwise optimization method. Acta Veterinaria Scandinavica 65(1), 41.

Return of sound production as a biomarker of bottlenose dolphin emergence from anesthesia

(1) Background: When a human or animal is recovering from general anesthesia, their medical team uses several behavioral and physiological parameters to assess their emergence from the unconscious state to complete wakefulness. However, the return of auditory and acoustic behaviors...

Year Published: 2023Topics: Anesthesia & SedationAnimal Type: Marine Mammal

Citation: Jones, B. L., McClain, A. M., Sportelli, J. J. et al. 2023. Return of sound production as a biomarker of bottlenose dolphin emergence from anesthesia. Animals 13(15), 2531.

Pig sedation and anesthesia for medical research

In clinical veterinary practice, proper training and expertise in anesthesia administration and monitoring are essential. Pigs are suitable experimental animals for many surgical techniques because they are similar in size to humans and have a short reproductive cycle. This makes...

Year Published: 2023Topics: Anesthesia & SedationAnimal Type: Pig

Citation: Costea, R., Ene, I., Pavel, R. 2023. Pig sedation and anesthesia for medical research. Animals 13(24), 3807.

Closed-loop control of anesthetic state in nonhuman primates

Research in human volunteers and surgical patients has shown that unconsciousness under general anesthesia can be reliably tracked using real-time electroencephalogram processing. Hence, a closed-loop anesthesia delivery (CLAD) system that maintains precisely specified levels of unconsciousness is feasible and would...

Year Published: 2023Topics: Anesthesia & SedationAnimal Type: Macaque, Nonhuman Primate

Citation: Chakravarty, S., Donoghue, J., Waite, A. S. et al. 2023. Closed-loop control of anesthetic state in nonhuman primates. PNAS Nexus 2(10), 293.

Comparative study of pain-related responses of male piglets up to seven days of age to the application of different local anaesthetics and subsequent castration

To evaluate pain responses to intratesticular and subscrotal injection of three local anaesthetics and their efficacy during castration a randomized controlled study was conducted. In groups of 20 piglets, procaine (2%), lidocaine (2%), or mepivacaine (2%) were administered subscrotal and...

Year Published: 2022Topics: Anesthesia & Sedation, Body Modification/MutilationAnimal Type: Pig

Citation: Söbbeler, F. J., Wendt, S., Briese, A. et al. 2022. Comparative study of pain-related responses of male piglets up to seven days of age to the application of different local anaesthetics and subsequent castration. Animals 12(20), 2833.

Perspective: Opportunities for advancing aquatic invertebrate welfare

Welfare considerations and regulations for invertebrates have lagged behind those for vertebrates, despite invertebrates comprising more than 95% of earth's species. Humans interact with and use aquatic invertebrates for exhibition in zoos and aquaria, as pets, research subjects, and important...

Year Published: 2022Topics: Analgesia, Anesthesia & Sedation, Biological Sampling & Physiological Measurement, EuthanasiaAnimal Type: Cephalopod, Crustacean, Invertebrate

Citation: Wahltinez, S. J., Stacy, N. I., Hadfield, C. A. et al. 2022. Perspective: Opportunities for advancing aquatic invertebrate welfare. Frontiers in Veterinary Science 9, 973376.

Antinociceptive, sedative and excitatory effects of intravenous butorphanol administed alone or in combination with detomidine in calves: A prospective, randomized, blinded cross-over study

The diagnostic and therapeutic procedures performed under sedation or general anesthesia in bovines are numerous. The analgesic drugs that can be legally used are few, making perioperative analgesia challenging. (2) Methods: Calves were administered butorphanol 0.1 mg kg−1 alone (SB)...

Year Published: 2023Topics: Anesthesia & SedationAnimal Type: Cattle

Citation: Maidanskaia, E. G., Mirra, A., Marchionatti, E. et al. 2023. Antinociceptive, sedative and excitatory effects of intravenous butorphanol administed alone or in combination with detomidine in calves: A prospective, randomized, blinded cross-over study. Animals 13(12), 1943.

Intranasal atomization of ketamine, medetomidine and butorphanol in pet rabbits using a mucosal atomization device

A non-invasive method of drug delivery, intranasal atomization, has shown positive results in human medicine and in some animal species. The objective of this study was to evaluate the effects of intranasal atomization, compared to intramuscular administration, of a mix...

Year Published: 2023Topics: Anesthesia & Sedation, Drug/Substance AdministrationAnimal Type: Rabbit

Citation: Mauthe von Degerfeld, M., Serpieri, M., Bonaffini, G. et al. 2023. Intranasal atomization of ketamine, medetomidine and butorphanol in pet rabbits using a mucosal atomization device. Animals 13(13), 2076.

How is depth of anaesthesia assessed in experimental pigs? A scoping review

Despite the large number of pigs involved in translational studies, no gold standard depth of anaesthesia indicators are available. We undertook a scoping review to investigate and summarize the evidence that sustains or contradicts the use of depth of anaesthesia...

Year Published: 2023Topics: Anesthesia & SedationAnimal Type: Pig

Citation: Mirra, A., Maidanskaia, E. G., Carmo, L. P. et al. 2023. How is depth of anaesthesia assessed in experimental pigs? A scoping review. PLOS ONE 18(3), e0283511.