Anesthesia & Sedation

Sedation efficacy of midazolam in conjunction with ketamine and alfaxalone in female laboratory guinea pigs (Cavia porcellus)

Guinea pigs have been integral as models used in biomedical research, making significant contributions to nutritional, auditory, immunologic, and hypersensitivity studies, and necessitating the routine need for sedation in laboratory settings. The ketamine-xylazine (KX) combination has been the standard sedation...

Year Published: 2024Topics: Anesthesia & SedationAnimal Type: Guinea Pig, Rodent

Citation: Wharton, K. N., Walsh, C. A., Haulter, M. et al. 2024. Sedation efficacy of midazolam in conjunction with ketamine and alfaxalone in female laboratory guinea pigs (Cavia porcellus). JAALAS 63(5), 572–580.

Comparison of propofol and alfaxalone as anesthesic drugs in bitches undergoing ovariohysterectomies (healthy bitches and with pyometra) and cesarean sections

This study evaluated the efficacy and safety of two anesthetic agents, alfaxalone and propofol, on maternal physiological parameters (heart and respiratory rates, blood pressure, and temperature) on either ovariohysterectomies or cesarean sections in bitches. A total of 34 healthy and...

Year Published: 2024Topics: Anesthesia & Sedation, ReproductionAnimal Type: Dog

Citation: Rodríguez-Trujillo, R., Batista-Arteaga, M., Iusupova, K. et al. 2024. Comparison of propofol and alfaxalone as anesthesic drugs in bitches undergoing ovariohysterectomies (healthy bitches and with pyometra) and cesarean sections. Animals 14(9), 1343.

Apneustic anesthesia ventilation improves pulmonary function in anesthetized bottlenose dolphins (Tursiops truncatus)

Our study suggests AAV, which more closely resembles the conscious intermittent respiratory pattern phenotype of dolphins, improves ventilation and pulmonary function in the anesthetized dolphin. Future studies should evaluate the cardiopulmonary effects of neutral buoyancy and cardiopulmonary sparing drug protocols...

Year Published: 2024Topics: Anesthesia & SedationAnimal Type: Marine Mammal

Citation: Le-Bert, C. R., Bukoski, A., Downs, J. et al. 2024. Apneustic anesthesia ventilation improves pulmonary function in anesthetized bottlenose dolphins (Tursiops truncatus). Frontiers in Veterinary Science 11.

Effects of vatinoxan in rats sedated with a combination of medetomidine, midazolam and fentanyl

Alpha2-adrenoceptor agonists (α2-agonists) are widely used in animals as sedatives and for pre-anaesthetic medication. Medetomidine has often been given subcutaneously (SC) to rats, although its absorption rate is slow and the individual variation in serum drug concentrations is high via...

Year Published: 2024Topics: Anesthesia & SedationAnimal Type: Rat, Rodent

Citation: Lindh, E., Meller, A., Raekallio, M. 2024. Effects of vatinoxan in rats sedated with a combination of medetomidine, midazolam and fentanyl. Acta Veterinaria Scandinavica 66(1), 23.

Eugenol as anesthetic for Cnesterodon decemmaculatus (Cyprinodontiformes, Poeciliidae)

Anesthetics are commonly used in fish for surgery and to facilitate capture, handling and transport in aquaculture and experimental procedures. In research, the selection of the anesthetic depends on its properties and on the recovery time. Eugenol has been pointed...

Year Published: 2024Topics: Anesthesia & SedationAnimal Type: Fish, Other Fish

Citation: Vercellini, M. C., Rearte, R., di Cesare, L. et al. 2024. Eugenol as anesthetic for Cnesterodon decemmaculatus (Cyprinodontiformes, Poeciliidae). Laboratory Animals 58(1), 44–51.

Evaluation of the quality of recovery from general anesthesia in dogs with two different low doses of dexmedetomidine

The purpose of this study was to evaluate the quality of recovery from general anesthesia with the administration of two low doses of dexmedetomidine in canine patients. For this blind randomized clinical trial study, 30 dogs undergoing general anesthesia for...

Year Published: 2024Topics: Anesthesia & SedationAnimal Type: Dog

Citation: Di Franco, C., Nocera, I., Melanie, P. et al. 2024. Evaluation of the quality of recovery from general anesthesia in dogs with two different low doses of dexmedetomidine. Animals 14(9), 1383.

Combining melatonin with dexmedetomidine improves anesthesia in rats

Melatonin (ML) and dexmedetomidine (DM) are used separately as anesthetic premedication or as an anesthetic in humans and laboratory animals. In this study, we aimed to investigate the anesthetic properties of both drugs combined. The anesthetic effects of several combinations...

Year Published: 2024Topics: Anesthesia & SedationAnimal Type: Rat, Rodent

Citation: Cogo Pagella, J., Rodríguez, M. F., Frisina, F. et al. 2024. Combining melatonin with dexmedetomidine improves anesthesia in rats. Laboratory Animals 58(3), 277–280.

Improving rat welfare through the development of a peribulbar anaesthesia technique for ophthalmic procedures: A preliminary study

Rats are a commonly used animal model for the study of the pathogenesis and novel treatments of glaucoma, which is induced experimentally using invasive, painful procedures. Peribulbar anaesthesia (PBA) is frequently used in people and domestic animals prior to ophthalmic...

Year Published: 2024Topics: Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Eliav, A., Ofri, R., Brust, K. et al. 2024. Improving rat welfare through the development of a peribulbar anaesthesia technique for ophthalmic procedures: A preliminary study. Laboratory Animals 58(2), 116–126.

Anesthesia and humane euthanasia methods for king worm larvae (Zophobas morio)

A growing spotlight on insect welfare as research subjects, fodder for vertebrate animals, and patients for veterinarians highlights the need to establish humane euthanasia methods for these species. An insect of increasing commercial importance is the king worm (Zophobas morio),...

Year Published: 2024Topics: Anesthesia & Sedation, EuthanasiaAnimal Type: Invertebrate, Other Invertebrate

Citation: Lum, A. M., Keller, K. A. 2024. Anesthesia and humane euthanasia methods for king worm larvae (Zophobas morio). Zoo Biology 43(2), 164–168.

Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia

Tamoxifen-induced CreER-LoxP recombination is often used to induce spatiotemporally controlled gene deletion in genetically modified mice. Prior work has shown that tamoxifen and tamoxifen-induced CreER activation can have off-target effects that should be controlled. However, it has not yet been...

Year Published: 2023Topics: Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Rashbrook, V. S., Denti, L., Ruhrberg, C. 2023. Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia. Animal Welfare 32, e78.