Anesthesia & Sedation

Eugenol as anesthetic for Cnesterodon decemmaculatus (Cyprinodontiformes, Poeciliidae)

Anesthetics are commonly used in fish for surgery and to facilitate capture, handling and transport in aquaculture and experimental procedures. In research, the selection of the anesthetic depends on its properties and on the recovery time. Eugenol has been pointed...

Year Published: 2024Topics: Anesthesia & SedationAnimal Type: Fish, Other Fish

Citation: Vercellini, M. C., Rearte, R., di Cesare, L. et al. 2024. Eugenol as anesthetic for Cnesterodon decemmaculatus (Cyprinodontiformes, Poeciliidae). Laboratory Animals 58(1), 44–51.

Evaluation of the quality of recovery from general anesthesia in dogs with two different low doses of dexmedetomidine

The purpose of this study was to evaluate the quality of recovery from general anesthesia with the administration of two low doses of dexmedetomidine in canine patients. For this blind randomized clinical trial study, 30 dogs undergoing general anesthesia for...

Year Published: 2024Topics: Anesthesia & SedationAnimal Type: Dog

Citation: Di Franco, C., Nocera, I., Melanie, P. et al. 2024. Evaluation of the quality of recovery from general anesthesia in dogs with two different low doses of dexmedetomidine. Animals 14(9), 1383.

Combining melatonin with dexmedetomidine improves anesthesia in rats

Melatonin (ML) and dexmedetomidine (DM) are used separately as anesthetic premedication or as an anesthetic in humans and laboratory animals. In this study, we aimed to investigate the anesthetic properties of both drugs combined. The anesthetic effects of several combinations...

Year Published: 2024Topics: Anesthesia & SedationAnimal Type: Rat, Rodent

Citation: Cogo Pagella, J., Rodríguez, M. F., Frisina, F. et al. 2024. Combining melatonin with dexmedetomidine improves anesthesia in rats. Laboratory Animals 58(3), 277–280.

Improving rat welfare through the development of a peribulbar anaesthesia technique for ophthalmic procedures: A preliminary study

Rats are a commonly used animal model for the study of the pathogenesis and novel treatments of glaucoma, which is induced experimentally using invasive, painful procedures. Peribulbar anaesthesia (PBA) is frequently used in people and domestic animals prior to ophthalmic...

Year Published: 2024Topics: Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Eliav, A., Ofri, R., Brust, K. et al. 2024. Improving rat welfare through the development of a peribulbar anaesthesia technique for ophthalmic procedures: A preliminary study. Laboratory Animals 58(2), 116–126.

Anesthesia and humane euthanasia methods for king worm larvae (Zophobas morio)

A growing spotlight on insect welfare as research subjects, fodder for vertebrate animals, and patients for veterinarians highlights the need to establish humane euthanasia methods for these species. An insect of increasing commercial importance is the king worm (Zophobas morio),...

Year Published: 2024Topics: Anesthesia & Sedation, EuthanasiaAnimal Type: Invertebrate, Other Invertebrate

Citation: Lum, A. M., Keller, K. A. 2024. Anesthesia and humane euthanasia methods for king worm larvae (Zophobas morio). Zoo Biology 43(2), 164–168.

Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia

Tamoxifen-induced CreER-LoxP recombination is often used to induce spatiotemporally controlled gene deletion in genetically modified mice. Prior work has shown that tamoxifen and tamoxifen-induced CreER activation can have off-target effects that should be controlled. However, it has not yet been...

Year Published: 2023Topics: Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Rashbrook, V. S., Denti, L., Ruhrberg, C. 2023. Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia. Animal Welfare 32, e78.

Mouse isoflurane anesthesia using the drop method

Anesthesia with isoflurane prior to carbon dioxide euthanasia is recommended as a refinement, but vaporizer access can be limited. An alternative to vaporizers is the ‘drop' method, introducing a fixed volume of isoflurane into the induction chamber. Previous work suggests...

Year Published: 2023Topics: Anesthesia & Sedation, EuthanasiaAnimal Type: Mouse, Rodent

Citation: Bodnar, M. J., Ratuski, A. S., Weary, D. M. 2023. Mouse isoflurane anesthesia using the drop method. Laboratory Animals 57(6), 623–630.

A review of long-acting parenteral analgesics for mice and rats

Appropriate analgesia is a crucial part of rodent postoperative and postprocedural pain. Providing appropriate analgesia is an ethical obligation, a regulatory requirement, and an essential element of obtaining quality scientific results and conducting reproducible data. Meeting these requirements is facilitated...

Year Published: 2022Topics: Anesthesia & SedationAnimal Type: Mouse, Rat, Rodent

Citation: Huss, M. K., Pacharinsak, C. 2022. A review of long-acting parenteral analgesics for mice and rats. JAALAS 61(6), 595–602.

Comparison of tricaine methanesulfonate (MS-222) and alfaxalone anesthesia in zebrafish (Danio rerio)

The research use of zebrafish has risen exponentially over the past decade while anesthetic options have remained largely unchanged.6 ricaine methanesulfonate (MS-222) is widely accepted as an anesthetic for routine husbandry procedures, however it has limitations and safety concerns. 11...

Year Published: 2024Topics: Anesthesia & SedationAnimal Type: Fish, Zebrafish

Citation: Weaver, H. L., Carbaugh, C. M., Madejczyk, M. S. et al. 2024. Comparison of tricaine methanesulfonate (MS-222) and alfaxalone anesthesia in zebrafish (Danio rerio). JAALAS 63(1), 74–80.

Use of alfaxalone in bearded dragons (Pogona vitticeps): Optimizing pharmacodynamics and evaluating cardiogenic effects via echocardiography

OBJECTIVE Bearded dragons (Pogona vitticeps), a popular zoological companion species, frequently require sedation for procedures. A novel formulation of alfaxalone with preservatives was FDA approved for 28-day use after the vial is breached. Research has been performed in squamate species...

Year Published: 2023Topics: Anesthesia & SedationAnimal Type: Lizard, Reptile

Citation: Webb, J. K., Keller, K. A., Chinnadurai, S. K. et al. 2023. Use of alfaxalone in bearded dragons (Pogona vitticeps): Optimizing pharmacodynamics and evaluating cardiogenic effects via echocardiography. Journal of the American Veterinary Medical Association 261(1), 126–131.