Publications

Psychosocial stress, glucocorticoids, and structural alterations in the tree shrew hippocampus

Animal models for chronic stress represent an indispensable preclinical approach to human pathology since clinical data point to a major role of psychological stress experiences, acute and/or chronic, to the development of behavioral and physiological disturbances. Chronic emotional arousal is...

Year Published: 2001Topics: Social Housing & CompanionshipAnimal Type: Tree Shrew

Citation: Fuchs, E., Flügge, G., Ohl, F. et al. 2001. Psychosocial stress, glucocorticoids, and structural alterations in the tree shrew hippocampus. Physiology & Behavior 73(3), 285–291.

Long term impacts of early social environment on chimpanzee white matter

Early adverse rearing conditions are known to have deleterious consequences on social behavior, cognition, and brain development of both human and nonhuman primates. We analyzed archival diffusion tensor imaging (DTI) data from mother- (MR) or nursery-reared (NR) chimpanzees and used...

Year Published: 2024Topics: Social Housing & CompanionshipAnimal Type: Chimpanzee, Nonhuman Primate

Citation: Mulholland, M. M., Hecht, E., Wesley, M. J. et al. 2024. Long term impacts of early social environment on chimpanzee white matter. Scientific Reports 14(1), 29879.

Social stress in tree shrews: Effects on physiology, brain function, and behavior of subordinate individuals

Social stress is known to be involved in the etiology of central nervous disorders such as depression. In recent years, animal models have been developed that use chronic stress to induce neuroendocrine and central nervous changes that might be similar...

Year Published: 2002Topics: Social Housing & CompanionshipAnimal Type: Tree Shrew

Citation: Fuchs, E., Flügge, G. 2002. Social stress in tree shrews: Effects on physiology, brain function, and behavior of subordinate individuals. Pharmacology Biochemistry and Behavior 73(1), 247–258.

The stress of being alone: Removal from the colony, but not social subordination, increases fecal cortisol metabolite levels in eusocial naked mole-rats

In many social species, hierarchical status within the group is associated with differences in basal adrenocortical activity. We examined this relationship in naked mole-rats (Heterocephalus glaber), eusocial rodents with arguably the most extreme social hierarchies of all mammals. This species...

Year Published: 2020Topics: Social Housing & CompanionshipAnimal Type: Mole Rat, Rodent

Citation: Edwards, P. D., Mooney, S. J., Bosson, C. O. et al. 2020. The stress of being alone: Removal from the colony, but not social subordination, increases fecal cortisol metabolite levels in eusocial naked mole-rats. Hormones and Behavior 121, 104720.

Using a length-weight relationship based on wild lumpfish (Cyclopterus lumpus L

The use of lumpfish (Cyclopterus lumpus L.) as cleaner fish in Atlantic salmon aquaculture has emerged as a promising solution to combat the issue of sea lice infestation, as they have proven effective under the right conditions. The aquaculture industry,...

Year Published: 2024Topics: Welfare AssessmentAnimal Type: Fish, Other Fish

Citation: Østerø, S. L., Toro, J. D., Homrum, E. í et al. 2024. Using a length-weight relationship based on wild lumpfish (Cyclopterus lumpus L.) for estimation of body condition of lumpfish in salmon cages. PLOS ONE 19(11), e0310924.

Hands-on refinements: Establishing improved husbandry processes for aged C57BL/6 mice

The main aim of this project was to review the husbandry processes in place for the colony of aged C57BL/6 mice at the Babraham Institute, establish a refined husbandry process and improve local guidance. Secondly, by analysing fate and clinical...

Year Published: 2024Topics: Husbandry & Management, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Paterson, A. 2024. Hands-on refinements: Establishing improved husbandry processes for aged C57BL/6 mice. Animal Technology and Welfare 23(2), 129–131.

“Killing in the name of 3R?” The ethics of death in animal research

Changing relationships with nonhuman animals have led to important modifications in animal welfare legislations, including the protection of animal life. However, animal research regulations are largely based on welfarist assumptions, neglecting the idea that death can constitute a harm to...

Year Published: 2024Topics: Euthanasia, Regulations & Ethical ReviewAnimal Type: All/General

Citation: Persson, K., Rodriguez Perez, C., Louis-Maerten, E. et al. 2024. “Killing in the name of 3R?” The ethics of death in animal research. Journal of Agricultural and Environmental Ethics 38(1), 4.

Forage, freedom of movement, and social interactions remain essential fundamentals for the welfare of high-level sport horses

Societal concerns for animal welfare extend to all domestic species, including high-level sport horses. The welfare of these horses, notably highlighted during the recent Olympics, has garnered significant public interest, prompting inquiries into their living conditions. Animal welfare studies have...

Year Published: 2024Topics: Husbandry & Management, Social Housing & CompanionshipAnimal Type: Equine

Citation: Phelipon, R., Hennes, N., Ruet, A. et al. 2024. Forage, freedom of movement, and social interactions remain essential fundamentals for the welfare of high-level sport horses. Frontiers in Veterinary Science 11.

Testing perioperative meloxicam analgesia to enhance welfare while preserving model validity in an inflammation-induced seizure model

Despite the international effort to improve laboratory animal welfare through the 3R principles (Reduce, Refine, Replace), many scientists still fail to implement and report their assessment of pain and well-being, likely due to concerns regarding the potential effects of analgesics...

Year Published: 2024Topics: Analgesia, Disease/Experimental Model, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Weiß, E., Pauletti, A., Egilmez, A. et al. 2024. Testing perioperative meloxicam analgesia to enhance welfare while preserving model validity in an inflammation-induced seizure model. Scientific Reports 14(1), 30563.

Investigating the effect a single dose of cannabidiol has on measures of stress in cats when being transported in a carrier and meeting a novel person in an unfamiliar environment

Domestic cats (Felis Catus) are often exposed to stimuli that have the potential to negatively impact their welfare. These can include situations such as veterinary visits, travel, changes to their home environment, and interactions with unfamiliar people or pets. Cannabidiol...

Year Published: 2024Topics: Relocation & TransportAnimal Type: Cat

Citation: Weller, J. E., Flint, H. E., Hunt, A. B. G. et al. 2024. Investigating the effect a single dose of cannabidiol has on measures of stress in cats when being transported in a carrier and meeting a novel person in an unfamiliar environment. Frontiers in Veterinary Science 11.