Publications

Non-invasive 3D time-of-flight imaging technique for tumour volume assessment in subcutaneous models

Subcutaneous tumour xenograft volumes are generally measured using callipers. This method is susceptible to inter- and intra-observer variability and systematic inaccuracies. Non-invasive 3D measurement using ultrasound and magnetic resonance imaging (MRI) have been considered, but require immobilization of the animal....

Year Published: 2015Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Delgado San Martin, J. A., Worthington, P., Yates, J. W. T. 2015. Non-invasive 3D time-of-flight imaging technique for tumour volume assessment in subcutaneous models. Laboratory Animals 49(2), 168-171.

Standardized environmental enrichment supports enhanced brain plasticity in healthy rats and prevents cognitive impairment in epileptic rats

Environmental enrichment of laboratory animals influences brain plasticity, stimulates neurogenesis, increases neurotrophic factor expression, and protects against the effects of brain insult. However, these positive effects are not constantly observed, probably because standardized procedures of environmental enrichment are lacking. Therefore,...

Year Published: 2013Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Fares, R. P., Belmeguenai, A., Sanchez, P.E. et al. 2013. Standardized environmental enrichment supports enhanced brain plasticity in healthy rats and prevents cognitive impairment in epileptic rats. PLOS ONE 8(1): e53888.

Larger cages with housing unit environment enrichment improve the welfare of marmosets

The provision of adequate space for laboratory animals is essential not only for good welfare but accurate studies. For example, housing conditions for primates used in biomedical research may negatively affect welfare and thus the reliability of findings. In common...

Year Published: 2018Topics: Environmental Enrichment, HousingAnimal Type: Macaque, Nonhuman Primate

Citation: Yoshimoto, T., Takahashi, E., Yamashita, S. et al. 2018. Larger cages with housing unit environment enrichment improve the welfare of marmosets. Experimental Animals 67(1), 31-39.

Transportation of Laboratory Animals: Proceedings of a Workshop

To examine these issues [transportation of laboratory animals], the Roundtable on Science and Welfare in Laboratory Animal Use held a workshop on September 3-4, 2014, in Washington, DC. More than 200 people participated in the workshop in person and online,...

Year Published: 2017Topics: Relocation & TransportAnimal Type: All/General

Citation: National Academies of Sciences, Engineering, and Medicine. 2017. Transportation of Laboratory Animals: Proceedings of a Workshop. The National Academies Press: Washington, DC, 106 pp.

Mymou: A low-cost, wireless touchscreen system for automated training of nonhuman primates

Training nonhuman primates (NHPs) to perform cognitive tasks is essential for many neuroscientific investigations, yet laboratory training is a time-consuming process with inherent limitations. Habituating NHPs to the laboratory staff and experimental equipment can take months before NHPs are ready...

Year Published: 2019Topics: Animal TrainingAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Butler, J. L., Kennerley, S. W. 2019. Mymou: A low-cost, wireless touchscreen system for automated training of nonhuman primates. Behaviour Research Methods 51, 2559–2572.

Effect of concrete slats, three mat types and out-wintering pads on performance and welfare of finishing beef steers

The objective was to investigate the effect of placing mats on concrete slatted floors on performance, behaviour, hoof condition, dirt scores, physiological and immunological variables of beef steers, and to compare responses with animals on out-wintering pads. Continental crossbred beef...

Year Published: 2017Topics: Husbandry & ManagementAnimal Type: Cattle

Citation: Earley, B., McNamara, J. D., Jerrams, S. J. et al. 2017. Effect of concrete slats, three mat types and out-wintering pads on performance and welfare of finishing beef steers. Acta Veterinaria Scandinavica 59(1), 34.

Personality, environmental stressors, and diarrhea in Rhesus macaques: An interactionist perspective

Previous research has repeatedly shown both personality and psychological stress to predict gastrointestinal disorders and chronic diarrhea in humans. The goal of the present research was to evaluate the role of personality, as well as psychological stressors (i.e., housing relocation...

Year Published: 2018Topics: Husbandry & Management, Personality, Relocation & TransportAnimal Type: Macaque, Nonhuman Primate

Citation: Gottlieb, D. H., Del Rosso, L, Sheikhi, F. et al. 2018. Personality, environmental stressors, and diarrhea in Rhesus macaques: An interactionist perspective. American Journal of Primatology 80(12), e22908.

Coping style and cortisol levels in infancy predict hair cortisol following new group formation in captive rhesus macaques (Macaca mulatta)

Social instability in primate groups has been used as a model to understand how social stress affects human populations. While it is well established that individual cercopithecines have different temperaments or personalities, little is known about how temperament mediates the...

Year Published: 2018Topics: Husbandry & Management, PersonalityAnimal Type: Macaque, Nonhuman Primate

Citation: Linden, J.B., Capitanio, J.P., McCowan, B. et al. 2018. Coping style and cortisol levels in infancy predict hair cortisol following new group formation in captive rhesus macaques (Macaca mulatta). American Journal of Primatology 80(12), e22938.

A comparison of desensitization techniques to train rhesus macaques to take food from a human

Some primates express fear of or avoid interaction with humans, including accepting food. Counter‐conditioning training designed to reduce fear and increase the acceptance of food from a person's hand can reduce the stress an animal experiences and serve as a...

Year Published: 2018Topics: Animal TrainingAnimal Type: Macaque, Nonhuman Primate

Citation: Franklin, A. N., Martin, A. L., Brennan, C. R. et al. 2018. A comparison of desensitization techniques to train rhesus macaques to take food from a human. American Journal of Primatology 80(S1), 13 (40th Meeting of the American Society of Primatologists Scientific Program, Abstract #5).

An assessment of porches as enrichment for singly housed cynomolgus macaques (Macaca fascicularis)

Effective environmental enrichment encourages usage, promotes species‐typical behaviors, and/or decreases abnormal behaviors. Porches are small cages that attach to the primary cage of an animal to provide additional space and a better view of the surroundings. This study aimed to...

Year Published: 2018Topics: Environmental Enrichment, HousingAnimal Type: Macaque, Nonhuman Primate

Citation: Brown, T. A., Lutz, C. K., 2018. An assessment of porches as enrichment for singly housed cynomolgus macaques (Macaca fascicularis). American Journal of Primatology 80(S1), 18 (40th Meeting of the American Society of Primatologists Scientific Program, Abstract #21).