Publications

Oral application of clozapine-N-oxide using the micropipette-guided drug administration (MDA) method in mouse DREADD systems

The designer receptor exclusively activated by designer drugs (DREADD) system is one of the most widely used chemogenetic techniques to modulate the activity of cell populations in the brains of behaving animals. DREADDs are activated by acute or chronic administration...

Year Published: 2021Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Schalbetter, S. M., Mueller, F. S., Scarborough, J. et al. 2021. Oral application of clozapine-N-oxide using the micropipette-guided drug administration (MDA) method in mouse DREADD systems. Lab Animal 50, 69-75.

Refining the unilateral ureteral obstruction mouse model: No sham, no shame

Fibrosis, as a common final pathway in many renal diseases, contributes significantly to the decline of organ function and to progression to end-stage renal disease. To establish therapeutic interventions that target fibrosis, animal models are essential. The most widely used...

Year Published: 2021Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Atkinson, J., Boden, T., Mocho J.-P. et al. 2021. Refining the unilateral ureteral obstruction mouse model: No sham, no shame. Laboratory Animals 55(1), 21-29.

Application of the 3R principles: Vertebrae as an additional source of murine bone-marrow cells

Experimental murine models are an essential tool in the field of bone marrow (BM) transplantation research. Therefore, numerous mice are required to obtain a sufficient number of BM cells, which is in contrast with the Reduction principle of the 3R...

Year Published: 2021Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Justin, M., Jež, M., Košir, A. et al. 2021. Application of the 3R principles: Vertebrae as an additional source of murine bone-marrow cells. Laboratory Animals 55(1), 43-52.

An alternative method for oral drug administration by voluntary intake in male and female mice

Drug administration to experimental rodents is often invasive and stressful, thus reducing animal welfare and potentially confounding experimental results. Methods of oral drug delivery in which rodents cooperate voluntarily minimize stress, pain and morbidity. We herein describe a method for oral...

Year Published: 2021Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Teixeira-Santos, L., Albino-Teixeira, A., Pinho, D. 2021. An alternative method for oral drug administration by voluntary intake in male and female mice. Laboratory Animals 55(1), 76-80.

Applications of behavioral training to laboratory animals

How many of us have had this experience? We go to a conference, we read an article, we watch a video. We understand operant conditioning. We grasp the concepts behind clicker training, target training, and how we are supposed to...

Year Published: 2021Topics: Animal TrainingAnimal Type: All/General, Pig, Sheep

Citation: Shyan-Norwalt, M. 2021. Applications of behavioral training to laboratory animals. Laboratory Animal Science Professional 9(1) (January/February), 13-15.

The basics: Getting started with animal training in LAS

Professional animal trainer now Animal Health Technician explains various animal training terms and concepts.

Year Published: 2021Topics: Animal TrainingAnimal Type: All/General

Citation: Buehler, A. 2021. The basics: Getting started with animal training in LAS. Laboratory Animal Science Professional 9(1) (January/February), 17-19.

DIY: Ice cream cone spiced foraging cups

This DIY snack is great for NHPs and can be customized in a variety of ways.

Year Published: 2021Topics: Environmental EnrichmentAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Lambert, K. 2021. DIY: Ice cream cone spiced foraging cups. Laboratory Animal Science Professional 9(1) (January/February), 36.

It takes a village: A case study in improving animal welfare with a team approach

There are many factors that need to be considered when caring for groups of nonhuman primates (NHPs) in research, including clinical, behavioral, and scientific issues. Otherwise, there is the potential that decisions are made without taking all these needs into...

Year Published: 2021Topics: Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Bader, L., Janavaris, M., Coleman, K. et al. 2021. It takes a village: A case study in improving animal welfare with a team approach. Laboratory Animal Science Professional 9(1) (January/February), 38-40.

Cooperative pig training that literally saves your back

This article describes the successful training of a pig to wear a jacket.

Year Published: 2021Topics: Animal TrainingAnimal Type: Pig

Citation: Combs, S. R., Lambert, K. 2021. Cooperative pig training that literally saves your back. Laboratory Animal Science Professional 9(1) (January/February), 42-45.

Using positive reinforcement training to build compliance in Sinclair mini pigs

Pigs are an ideal model for treating osteochondral defects, though their sedentary nature could impair their healing when being used for one of these projects. Following joint injury, some level of lameness is anticipated. Developing a routine of exercise is...

Year Published: 2021Topics: Animal TrainingAnimal Type: Pig

Citation: Perez, J., Collins, R., Lambert, K. 2021. Using positive reinforcement training to build compliance in Sinclair mini pigs. Laboratory Animal Science Professional 9(1) (January/February), 50-53.