Publications

Modernization of wall guard railing for safe enrichment in feline housing facilities

Creatively adapting older lab animal housing spaces to improve psychological well-being, welfare, and safety for animals is necessary to meet expectations for animal enrichment. Traditional lab animal facilities are designed to have functional, flexible, durable, and sanitizable housing spaces. Many...

Year Published: 2022Topics: Environmental EnrichmentAnimal Type: Cat

Citation: Snipes, M. M., Wofford, K. A., Funk, A. L. et al. 2022. Modernization of wall guard railing for safe enrichment in feline housing facilities. Laboratory Animal Science Professional 10(5) (September/October), 50-51.

Environmental enrichment: Dissociated effects between physical activity and changing environmental complexity on anxiety and neurogenesis in adult male Balb/C mice

Several factors, including environmental modifications, stimulate neuroplasticity. One type of neuroplasticity consists in the generation of new neurons in the dentate gyrus of the hippocampus. Neurogenesis is modulated by environmental enrichment (ENR, tunnels plus running wheel) and affected by the...

Year Published: 2022Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Ramírez-Rodríguez, G. B., Gutiérrez-Vera, B., Ortiz-López, L. et al. 2022. Environmental enrichment: Dissociated effects between physical activity and changing environmental complexity on anxiety and neurogenesis in adult male Balb/C mice. Physiology & Behavior 254, 113878.

A multicentre study on spontaneous in-cage activity and micro-environmental conditions of IVC housed C57BL/6J mice during consecutive cycles of bi-weekly cage-change

Mice respond to a cage change (CC) with altered activity, disrupted sleep and increased anxiety. A bi-weekly cage change is, therefore, preferred over a shorter CC interval and is currently the prevailing routine for Individually ventilated cages (IVCs). However, the...

Year Published: 2022Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Ulfhake, B., Lerat, H., Honetschlager, J. et al. 2022. A multicentre study on spontaneous in-cage activity and micro-environmental conditions of IVC housed C57BL/6J mice during consecutive cycles of bi-weekly cage-change. PLOS ONE 17(5), e0267281.

Pivotal role of micro-CT technology in setting up an optimized lung fibrosis mouse model for drug screening

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with no curative pharmacological treatment. The most used animal model of IPF for anti-fibrotic drug screening is bleomycin (BLM)-induced lung fibrosis. However, several issues have been reported: the balance among disease resolution,...

Year Published: 2022Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Khalajzeyqami, Z., Grandi, A., Ferrini, E. et al. 2022. Pivotal role of micro-CT technology in setting up an optimized lung fibrosis mouse model for drug screening. PLOS ONE 17(6), e0270005.

Systematic review of animal-based indicators to measure thermal, social, and immune-related stress in pigs

The intense nature of pig production has increased the animals' exposure to stressful conditions, which may be detrimental to their welfare and productivity. Some of the most common sources of stress in pigs are extreme thermal conditions (thermal stress), density...

Year Published: 2022Topics: Welfare AssessmentAnimal Type: Pig

Citation: Guevara, R. D., Pastor, J. J., Manteca, X. et al. 2022. Systematic review of animal-based indicators to measure thermal, social, and immune-related stress in pigs. PLOS ONE 17(5), e0266524.

Dairy cows value an open area for lying down

As dairy cows are being housed for longer periods, with all-year-round housing growing in popularity, it is important to ensure housed environments are meeting the needs of cows. Dairy cows are motivated to access open lying areas, although previous motivation...

Year Published: 2022Topics: HousingAnimal Type: Cattle

Citation: Shewbridge Carter, L., Haskell, M. J., Ball, D. et al. 2022. Dairy cows value an open area for lying down. PLOS ONE 17(5), e0268238.

Introduction of gloved hand to cage induces 22-kHz ultrasonic vocalizations in male albino rats

Rodents emit ultrasonic vocalizations (USVs) above the human hearing threshold of ~ 20 kHz to communicate emotional states and to coordinate their social interactive behavior. Twenty-two kHz USVs emitted by adult rats have been reported in a variety of aversive...

Year Published: 2022Topics: Handling, Human-Animal InteractionAnimal Type: Rat, Rodent

Citation: Hwang, S.-K., Tyszkiewicz, C., Dragon, M. et al. 2022. Introduction of gloved hand to cage induces 22-kHz ultrasonic vocalizations in male albino rats. PLOS ONE 17(11), e0278034.

Cognitive enrichment in a social setting: Assessing the use of a novel food maze in sanctuary-housed chimpanzees

Foraging devices are effective enrichment tools for non-human primates, as they provide both cognitive and manipulative stimulation that may enhance these animals' welfare. We assessed the behavioral effects of a novel tool-based enrichment on 14 chimpanzees (Pan troglodytes) housed at...

Year Published: 2022Topics: Environmental EnrichmentAnimal Type: Chimpanzee, Nonhuman Primate

Citation: Padrell, M., Amici, F., Córdoba, M. P. et al. 2022. Cognitive enrichment in a social setting: Assessing the use of a novel food maze in sanctuary-housed chimpanzees. Primates 63(5), 509–524.

Waking inactivity as a welfare indicator in laboratory mice: Investigating postures, facial expressions and depression-like states

Animal welfare assessment relies on valid and practical indicators of affect. In mice, the most widely used research vertebrates, lying still with eyes open, inactive-but-awake (IBA) in the home cage, has potential to be one such indicator. IBA is elevated...

Year Published: 2022Topics: Emotion, Pain, & Sentience, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: MacLellan, A., Nazal, B., Young et al. 2022. Waking inactivity as a welfare indicator in laboratory mice: Investigating postures, facial expressions and depression-like states. Royal Society Open Science 9(11), 221083.

Anesthesia overdose versus rapid cooling for euthanasia of adult zebrafish

The rapid increase in zebrafish use needs to be accompanied by research into the refinement of procedures. The European (EU) Directive lists three possible euthanasia methods for fish: anesthetic overdose, electrical stunning, and concussion. However, for small fish such as...

Year Published: 2022Topics: EuthanasiaAnimal Type: Fish, Zebrafish

Citation: Ferreira, J. M., Félix, L., Jorge, S. et al. 2022. Anesthesia overdose versus rapid cooling for euthanasia of adult zebrafish. Zebrafish 19(4), 148-159.