Rodent

Four- and six-hour urinary albumin excretion is a valuable alternative to 24-h urinary albumin excretion in male db/db mice

In mouse (Mus musculus) models of diabetic nephropathy (DN), one of the most important read-outs is the 24-h urinary albumin excretion (UAE). The 24-h urine collection is usually performed by single housing mice in metabolic cages on wire mesh without...

Year Published: 2020Topics: Biological Sampling & Physiological Measurement, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Nøgaard, S. A., Sand, F. W., Sørensen, D. B. et al. 2020. Four- and six-hour urinary albumin excretion is a valuable alternative to 24-h urinary albumin excretion in male db/db mice. Animal Welfare 29(2), 143-149.

Humane euthanasia of guinea pigs (Cavia porcellus) with a penetrating spring-loaded captive bolt

Guinea pigs (Cavia porcellus) have been used in research since the 19th century to collect data due to their physiological similarities to humans. Today, animals perform a vital role in experiments and concerns for laboratory animal welfare are enshrined in...

Year Published: 2020Topics: EuthanasiaAnimal Type: Guinea Pig, Rodent

Citation: Cohen, S., Kwok, M., Huang, J. 2020. Humane euthanasia of guinea pigs (Cavia porcellus) with a penetrating spring-loaded captive bolt. Animals 10(8), 1356.

Identifying obstacles preventing the uptake of tunnel handling methods for laboratory mice: An international thematic survey

Handling of laboratory mice is essential for experiments and husbandry, but handling can increase anxiety in mice, compromising their welfare and potentially reducing replicability between studies. The use of non-aversive handling (e.g., tunnel handling or cupping), rather than the standard...

Year Published: 2020Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Henderson, L. J., Smulders, T. V., Roughan, J. V. 2020. Identifying obstacles preventing the uptake of tunnel handling methods for laboratory mice: An international thematic survey. PLOS ONE 15(4), e0231454.

Impact of enriched environment during adolescence on adult social behavior, hippocampal synaptic density and dopamine D2 receptor expression in rats

Environmental enrichment (EE) is one experimental manipulation that induces changes in the brain. However, it is important to distinguish between physical and social components of enrichment. To this end we established four groups of rats reared in different enriched environments...

Year Published: 2020Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Gabriel, P., Mastracchio, T., Bordner, K. et al. 2020. Impact of enriched environment during adolescence on adult social behavior, hippocampal synaptic density and dopamine D2 receptor expression in rats. Physiology & Behavior, 226, 113133.

Impact of three commonly used blood sampling techniques on the welfare of laboratory mice: Taking the animal’s perspective

Laboratory mice are the most frequently used animals in biomedical research. In accordance with guidelines for humane handling, several blood sampling techniques have been established. While the effects of these procedures on blood quality and histological alterations at the sampling...

Year Published: 2020Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Meyer, N., Kröger, M., Thümmler, J. et al. 2020. Impact of three commonly used blood sampling techniques on the welfare of laboratory mice: Taking the animal’s perspective. PLOS ONE 15(9), e0238895.

Improvement of the Mouse Grimace Scale set-up for implementing a semi-automated Mouse Grimace Scale scoring (Part 1)

The Mouse Grimace Scale (MGS) has been widely used for the noninvasive examination of distress/pain in mice. The aim of this study was to further improve its performance to generate repeatable, faster, blinded and reliable results for developing automated and...

Year Published: 2020Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Ernst, L., Kopaczka, M., Schulz, M. et al. 2020. Improvement of the Mouse Grimace Scale set-up for implementing a semi-automated Mouse Grimace Scale scoring (Part 1). Laboratory Animals 54(1), 83–91.

Impulse for animal welfare outside the experiment

Animal welfare is a growing societal concern and the well-being of animals used for experimental purposes is under particular scrutiny. The vast majority of laboratory animals are mice living in small cages that do not offer very much variety. Moreover,...

Year Published: 2020Topics: HousingAnimal Type: Mouse, Rodent

Citation: Lewejohann, L., Schwabe, K., Häger, C. et al. 2020. Impulse for animal welfare outside the experiment. Laboratory Animals 54(2), 150–158.

Infrared thermography as an indicator of heat loss in fur-chewing chinchillas (Chinchilla lanigera)

Fur-chewing is a common problem in chinchilla (Chinchilla lanigera). It may affect the welfare of animals due to heat loss, thereby possibly impacting food and water intake to maintain body temperature. In this context, infrared thermography seems to be a...

Year Published: 2020Topics: Abnormal/Problematic BehaviorAnimal Type: Chinchilla, Rodent

Citation: Łapiński, S., Orel, J., Niedbała, P. et al. 2020. Infrared thermography as an indicator of heat loss in fur-chewing chinchillas (Chinchilla lanigera). Journal of Applied Animal Welfare Science 23(3), 338-347.

Is that a rat in your pocket? A novel pocket method for rat restraint

At the University of Illinois at Urbana- Champaign (UIUC), we routinely teach novice research personnel how to appropriately handle, restrain, and perform basic experimental techniques on rats. Barriers to teaching include fear of animal bites to the handler, stress to...

Year Published: 2020Topics: RestraintAnimal Type: Rat, Rodent

Citation: Ludwig, J. L. 2020. Is that a rat in your pocket? A novel pocket method for rat restraint. Laboratory Animal Science Professional 8(1) (January/February), 48-49.

Isoflurane and carbon dioxide elicit similar behavioral responses in rats

Euthanasia in rodents is an ongoing topic of debate due to concerns regarding the aversive nature of gases with anesthetic properties such as carbon dioxide (CO2) and isoflurane. The aim of this study was to expand upon previously published work...

Year Published: 2020Topics: EuthanasiaAnimal Type: Rat, Rodent

Citation: Kulkarni, S., Hickman, D. 2020. Isoflurane and carbon dioxide elicit similar behavioral responses in rats. Animals 10(8), 1431.