Rat

Refining procedures within regulatory toxicology studies: Improving animal welfare and data

During the development of potential new medicines or agrochemicals, an assessment of the safety profile to humans and environmental species is conducted using a range of different in silico and in vitro techniques in conjunction with metabolism and toxicity studies...

Year Published: 2021Topics: Biological Sampling & Physiological Measurement, Cannulation, Catheterization, & Intubation, HousingAnimal Type: Dog, Fish, Mouse, Nonhuman Primate, Pig, Rabbit, Rat, Rodent

Citation: Prior, H., Blunt, H., Crossman, L. et al. 2021. Refining procedures within regulatory toxicology studies: Improving animal welfare and data. Animals 11(11), 3057.

Emulsified gels: A refined vehicle for accurate and rapid oral administration of lipid based preparations to rats

Oro-gastric gavage is used to accurately administer nutritional substances or drugs to animals. However, it induces stress and has a substantial risk of mishap. Incorporation into edible gels is difficult for lipid-based preparations. We report a new methodology for producing...

Year Published: 2021Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Satokar, V., Vickers, M., Bridge-Comer, P. et al. 2021. Emulsified gels: A refined vehicle for accurate and rapid oral administration of lipid based preparations to rats. Animal Technology and Welfare 20(2), 95-103.

Maximising efficacy of your health monitoring programme

There are a multitude of health monitoring techniques/ methods available. It can be difficult to know which of these to use and when to use them. This is an attempt to simplify, maximise the efficacy of and ultimately reduce the...

Year Published: 2021Topics: Husbandry & ManagementAnimal Type: Chinchilla, Gerbil, Guinea Pig, Hamster, Mouse, Rat, Rodent

Citation: Dickinson, A. 2021. Maximising efficacy of your health monitoring programme. Animal Technology and Welfare 20(3), 255-257.

A break from the pups: The effects of loft access on the welfare of lactating laboratory rats

Rats (Rattus norvegicus) bred for research are typically confined with their litters until weaning, but will spend time away from pups when given the opportunity. We aimed to assess how dam welfare is affected by the ability to escape from...

Year Published: 2021Topics: Rearing & WeaningAnimal Type: Rat, Rodent

Citation: Ratuski, A. S., Weary, D. M. 2021. A break from the pups: The effects of loft access on the welfare of lactating laboratory rats. PLOS ONE 16(6), e0253020.

Assessing the severity of laparotomy and partial hepatectomy in male rats—A multimodal approach

This study assessed the postoperative severity after three different visceral surgical interventions in rats by using objective parameters pertaining to various disciplines. The objective was to evaluate whether the degree of severity increases with the invasiveness of the intervention and...

Year Published: 2021Topics: Welfare AssessmentAnimal Type: Rat, Rodent

Citation: Zieglowski, L., Kümmecke, A. M., Ernst, L. et al. 2021. Assessing the severity of laparotomy and partial hepatectomy in male rats—A multimodal approach. PLOS ONE 16(8), e0255175.

A novel model of ischemia in rats with middle cerebral artery occlusion using a microcatheter and zirconia ball under fluoroscopy

Here, we present a highly selective rat MCAO model by percutaneous caudal arterial puncture using a microcatheter and zirconia ball under fluoroscopic guidance. The model is predictable and reproducible, which is well confined within the territory supplied by the MCA,...

Year Published: 2021Topics: Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Komatsu, T., Ohta, H., Motegi, H. et al. 2021. A novel model of ischemia in rats with middle cerebral artery occlusion using a microcatheter and zirconia ball under fluoroscopy. Scientific Reports 11(1), 12806.

Associations between clinical signs and pathological findings in toxicity testing

Animal testing for toxicity assessment of chemicals and pharmaceuticals must take the 3R principles into consideration. During toxicity testing in vivo, clinical signs are used to monitor animal welfare and to inform about potential toxicity. This study investigated possible associations...

Year Published: 2021Topics: Welfare AssessmentAnimal Type: Rat, Rodent

Citation: Silva, A. V., Norinder, U., Liiv, E. et al. 2021. Associations between clinical signs and pathological findings in toxicity testing. ALTEX 38(2), 198-214.

Alternative method of oral dosing for rats

Oral administration of drugs to laboratory rodents typically is achieved by using the gavage technique. Although highly effective, this method occasionally can cause esophageal injury as well as restraint-associated distress, particularly with repeated use. The aim of this study was...

Year Published: 2010Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Atcha, Z., Rourke, C., Neo, A. H. P. et al. 2010. Alternative method of oral dosing for rats. JAALAS 49(3), 335-343.

A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models

Purpose: Convenient and effective methods for administering potential antiepileptic drugs (AEDs) chronically should facilitate many experiments in animal models of chronic epilepsy with spontaneous recurrent seizures. This proof-of-principle study aimed to optimize a once-per-day, drug-in-food protocol by testing the effect...

Year Published: 2012Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Ali, A., Dua, Y., Constance, J. E. et al. 2012. A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models. Epilepsia 53(1), 199-206.

DIY: Dehydrated watermelon training chips

This simple DIY training treat is great for NHP, swine, rabbits, rodents, and dogs. Note that dehydrated watermelon may resemble muscle tissue!

Year Published: 2021Topics: Environmental EnrichmentAnimal Type: Baboon, Capuchin, Chimpanzee, Chinchilla, Dog, Gerbil, Guinea Pig, Hamster, Lemur, Macaque, Marmoset, Mouse, Nonhuman Primate, Other Nonhuman Primate, Other Rodent, Owl Monkey, Pig, Rabbit, Rat, Rodent, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Lambert, K. 2021. DIY: Dehydrated watermelon training chips. Laboratory Animal Science Professional 9(4) (July/August), 48.