Mouse

Do mice benefit from prefabricated dwellings? A discussion by the Laboratory Animal Refinement and Enrichment Forum

I conclude from our discussion that commercial prefabricated dwellings for mice are useful only if they are made of GLP-accepted material that the animals can readily gnaw and convert into nesting and bedding material. Since mice have a biologically inherent...

Year Published: 2006Topics: Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Barley, J., Francis, R., Van Loo, P. et al. 2006. Do mice benefit from prefabricated dwellings? A discussion by the Laboratory Animal Refinement and Enrichment Forum. Animal Technology and Welfare 5(1), 13-15.

Laboratory environments and rodents’ behavioural needs: a review

Laboratory housing conditions have significant physiological and psychological effects on rodents, raising both scientific and humane concerns. Published studies of rats, mice and other rodents were reviewed to document behavioural and psychological problems attributable to predominant laboratory housing conditions. Studies...

Year Published: 2006Animal Type: Mouse, Rat, Rodent

Citation: Balcombe, J. P. 2006. Laboratory environments and rodents' behavioural needs: a review. Laboratory Animals 40, 217-235.

Considerations for determining optimal mouse caging density

A meeting summary. The panel largely agreed that animal well-being should be the measure of interest in evaluating housing density and that well-being includes not only physical health, but also animals' behavior, productivity and preference.

Year Published: 2007Animal Type: Mouse, Rodent

Citation: Foltz, C., Carbone, L., DeLong, D. et al. 2007. Considerations for determining optimal mouse caging density. Lab Animal 36(10), 40-49.

Effects of cage size and enrichment on aggression and stereotypic behavior in three strains of laboratory mice

For female mice, increased complexity of space is more important than the quantity of space.

Year Published: 2007Topics: Abnormal/Problematic Behavior, Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Forsyth, N., Young, G., Mench, J. 2007. Effects of cage size and enrichment on aggression and stereotypic behavior in three strains of laboratory mice. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 26 (Abstract).

Integrated approaches to developing and implementing the 3Rs at MRC NIMR

A number of different 3Rs initiatives are described. Refinement: The use of methods that alleviate or minimise potential pain, suffering or distress, and enhance animal welfare. [p 131] At NIMR [National Institute for Medical Reserch], animal technicians led the work...

Year Published: 2007Animal Type: All/General, Mouse, Rodent

Citation: Fern, S. L. 2007. Integrated approaches to developing and implementing the 3Rs at MRC NIMR. Animal Technology and Welfare 6, 129-136.

Adaptation of a ladder beam walking task to assess locomotor recovery in mice following spinal cord injury

Locomotor impairments after spinal cord injury (SCI) are often assessed using open-field rating scales. These tasks have the advantage of spanning the range from complete paralysis to normal walking; however, they lack sensitivity at specific levels of recovery. Additionally, most...

Year Published: 2007Animal Type: Mouse, Rodent

Citation: Cummings, B. J., Engesser-Cesar, C., Cadena, G. et al. 2007. Adaptation of a ladder beam walking task to assess locomotor recovery in mice following spinal cord injury. Behavioral Brain Research 177, 232-241.

Anxiolytic effect of music depends on ovarian steroid in female mice

Mice exposed to music showed less anxiety than those exposed to white noise or silence.

Year Published: 2007Animal Type: Mouse, Rodent

Citation: Chikahisa, S., Sano, A., Kitaoka, K. et al. 2007. Anxiolytic effect of music depends on ovarian steroid in female mice. Behavioural Brain Research 179, 50-59.

Comparison of doxycycline delivery methods for tet-inducible gene expression ina subcutaneous xenograft model

Doxycycline (Dox) controlled Tet systems provide a powerful and commonly used method for functional studies on the consequences of gene overexpression/downregulation. However, whereas Dox delivery in tissue culture in vitro is relatively simple, the situation in vivo is more complex....

Year Published: 2007Animal Type: Mouse, Rodent

Citation: Cawthorne, C., Swindell, R., Stratford, I. J. et al. 2007. Comparison of doxycycline delivery methods for tet-inducible gene expression ina subcutaneous xenograft model. Journal of Biomolecular Techniques 18, 120-123.

The importance of exposure to other male scents in determining competitive behaviour among inbred male mice

We investigated the effect of repeated exposure to soiled bedding from males of either the same or different strain on competitive urine counter-marking and investigation and on aggressive behaviour within same-strain pairs of BALB/c and C57BL/6 males. Males pre-exposed to...

Year Published: 2007Animal Type: Mouse, Rodent

Citation: Lacey, J. C., Beynon, R. J., Hurst, J. L. 2007. The importance of exposure to other male scents in determining competitive behaviour among inbred male mice. Applied Animal Behaviour Science 104(1-2), 130-142.

The influence of the location of a nest box in an individually ventilated cage on the preference of mice to use it

The study concluded that the location of the nest boxes in the individually ventilated cage (on the cage floor or hung from the cage lid) can give animals a choice to modify their environment and to choose what to use...

Year Published: 2007Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Kostomitsopoulos, N. G., Paronis, E., Alexakos, P. et al. 2007. The influence of the location of a nest box in an individually ventilated cage on the preference of mice to use it. Journal of Applied Animal Welfare Science 10(2), 111-121.