Mouse

Laboratory routines cause animal stress

Based on a literature review the conclusion was drawn that routine handling, venipuncture, and orogastic gavage lead to elevations of heart rate, blood pressure, and glucocorticoid concentrations that persist for 30 to 60 min or more following the event, suggesting...

Year Published: 2004Animal Type: All/General, Mouse, Nonhuman Primate, Rat, Rodent

Citation: Balcombe, J. P., Barnard, N. D., Sandusky, C. 2004. Laboratory routines cause animal stress. Contemporary Topics in Laboratory Animal Science 43(6), 42-51.

Environmental enrichment improves cognition in aged Alzheimer’s transgenic mice despite stable beta-amyloid deposition

Environmental enrichment (EE) has been shown to improve cognitive performance and brain indices of cognition in normal mice and rats. .. Beginning at 16 months of age, APPsw mice were put into EE or standard housing for 4 months and...

Year Published: 2004Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Arendash, G. W., Garcia, M. F., Costa, D. A. et al. 2004 . Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition. Neuroreport 15 , 1751-1754.

Environmental enrichment for laboratory rodents and rabbits: Requirements of rodents, rabbits, and research

Environmental conditions such as housing and husbandry have a major impact on the laboratory animal throughout its life and will thereby influence the outcome of animal experiments. However, housing systems for laboratory animals have often been designed on the basis...

Year Published: 2005Topics: Environmental EnrichmentAnimal Type: Gerbil, Guinea Pig, Hamster, Mouse, Rabbit, Rat, Rodent

Citation: Baumans, V. 2005. Environmental enrichment for laboratory rodents and rabbits: Requirements of rodents, rabbits, and research. ILAR Journal 46(2), 162-170.

Potential for unintended consequences of environmental enrihment for laboratory animals and research results

Many aspects of the research animal's housing environment are controlled for quality and/or standardization. Of recent interest is the potential for environmental enrichment to have unexpected consequences such as unintended harm to the animal, or the introduction of variability into...

Year Published: 2005Topics: Environmental Enrichment, Husbandry & Management, Social Housing & CompanionshipAnimal Type: Hamster, Macaque, Mouse, Nonhuman Primate, Rabbit, Rat, Rodent

Citation: Bayne, K. 2005. Potential for unintended consequences of environmental enrihment for laboratory animals and research results. ILAR Journal 46(2), 129-139.

Multiple housing of male CD-1 mice for toxicological studies

Aggression peaked around 10 weeks into the [10 months] study and was usually observed following dosing or cage cleaning, ceasing once human activities in the room were completed.

Year Published: 2005Animal Type: Mouse, Rodent

Citation: Bolam, S. 2005. Multiple housing of male CD-1 mice for toxicological studies. Animal Technology and Welfare 4, 86-87.

Behavioral assessment of intermittent wheel running and individual housing in mice in the laboratory

It can be concluded that both socially and physically enriched environments do not influence wheel running frequency patterns.

Year Published: 2005Animal Type: Mouse, Rodent

Citation: Pham, T. M., Brene, S., Baumans, V. 2005. Behavioral assessment of intermittent wheel running and individual housing in mice in the laboratory. Journal of Applied Animal Welfare Science 8, 157-173.

Breeding colony housing: A comparison of two cages sized

Based on our findings we determined that large boxes [8 x 17 in. versus small 6 x 10 in. standard boxes] improved breeding performance [of breeding C57BL/6 mice], required less labor, and provided a better microenvironment.

Year Published: 2005Animal Type: Mouse, Rodent

Citation: McMahon, K., Haist, C., Dysko, R. 2005. Breeding colony housing: A comparison of two cages sized. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 127(Abstract).

Collecting blood from rodents: A discussion by the Laboratory Animal Refinement and Enrichment Forum

The question was asked: "In your own experience, what is the least disturbing technique - from the subject's point of view! - of blood collection for rodents?" In summary, it is fair to conclude the clinical and ethical concerns outweigh...

Year Published: 2005Topics: Biological Sampling & Physiological MeasurementAnimal Type: Chinchilla, Gerbil, Guinea Pig, Hamster, Mouse, Other Rodent, Rat, Rodent

Citation: Luzzi, M., Skoumbourdis, E., Baumans, V. et al. 2005. Collecting blood from rodents: A discussion by the Laboratory Animal Refinement and Enrichment Forum. Animal Technology and Welfare 4, 99-102.

Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

Cerebral deposition of beta-amyloid (Abeta) peptides is an invariant pathological hallmark in brains of patients with Alzheimer's disease (AD) and transgenic mice coexpressing familial AD-linked APP and PS1 variants. We now report that exposure of transgenic mice to an enriched...

Year Published: 2005Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Lazarov, O., Robinson, J., Tang, Y. P. et al. 2005. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 120, 701-713.

Environmental enrichment for laboratory rodents

In this article, laws and guidelines relating to rodent enrichment are reviewed, the natural behaviors of select rodent species are discussed, and an overview of widely used types of enrichment in laboratory rodent management is provided. Survey data on current...

Year Published: 2005Topics: Environmental Enrichment, Natural Behavior, Regulations & Ethical ReviewAnimal Type: Guinea Pig, Hamster, Mouse, Rat, Rodent

Citation: Hutchinson, E., Avery, A., Van de Woude, S. 2005. Environmental enrichment for laboratory rodents. ILAR Journal 46(2), 148-161.