Mouse

Evaluation of a synthetic bedding substrate for mice (Mus musculus)

This study compared a synthetic bedding substrate (SBS), which has the potential to be a particulate-free animal bedding system, with the standard woodchip bedding. The objective was to demonstrate that the SBS is habitable for mice and reduces particulates to...

Year Published: 2019Topics: Housing, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Bellin, M. A., Reitnauer, K. J., Gomez, A. M. et al. 2019. Evaluation of a synthetic bedding substrate for mice (Mus musculus). JAALAS 58(2), 154-159.

Time-dependent pathologic and inflammatory consequences of various blood sampling techniques in mice

We compared 6 frequently used mouse blood-sampling methods (lateral tail incision; tail-tip amputation; sublingual, submandibular, and saphenous vein puncture; and retrobulbar sinus puncture during isoflurane anesthesia) with regard to induction of local and systemic inflammation, stomach contents, weight changes, and...

Year Published: 2019Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Sørensen, D. B., Metzdorff, S. B., Jensen, L. K. et al. 2019. Time-dependent pathologic and inflammatory consequences of various blood sampling techniques in mice. JAALAS 58(3), 362-372.

Assessment of pain associated with the injection of sodium pentobarbital in laboratory mice (Mus musculus)

The AVMA Guidelines for the Euthanasia of Animals considers injection of barbiturates to be an acceptable method of euthanasia in rodents but states there is a potential for pain when administered intraperitoneally. This study examined the potential for pain in...

Year Published: 2019Topics: Drug/Substance Administration, EuthanasiaAnimal Type: Mouse, Rodent

Citation: Dutton III, J. W., Artwohl, J. E., Huang, X. et al. 2019. Assessment of pain associated with the injection of sodium pentobarbital in laboratory mice (Mus musculus). JAALAS 58(3), 373-379.

Clinical, physiologic, and behavioral evaluation of permanently catheterized NMRI mice

Vascular catheterization is becoming a popular technique in laboratory rodents, facilitating repetitive blood sampling and infusion in individual animals. In mice, catheterization is complicated by their small body size, which may increase the risk of postoperative complications that may both...

Year Published: 2019Topics: Cannulation, Catheterization, & IntubationAnimal Type: Mouse, Rodent

Citation: Falkenberg, M. K., Teilmann, A. C., Henriksen, T. et al. 2019. Clinical, physiologic, and behavioral evaluation of permanently catheterized NMRI mice. JAALAS 58(3), 380-389.

The role of emotional contagion in the distress exhibited by grouped mice exposed to CO2

The 2013 AVMA Guidelines for the Euthanasia of Animals recommends a chamber volume displacement rate of 10% to 30% per minute (v/min) when euthanizing small laboratory rodents with CO2. Group euthanasia of mice is a common practice, and grouping strangers...

Year Published: 2019Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Moffitt, A. D., Brignolo, L. L., Ardeshir, A. et al. 2019. The role of emotional contagion in the distress exhibited by grouped mice exposed to CO2. JAALAS 58(4), 430-437.

Physiologic stress of ear punch identification compared with restraint only in mice

Social housing of laboratory rodents is recommended whenever possible to encourage natural behavior and social dynamics. Several identification methods are used to distinguish rodents from one another. One of the most common means of identifying mice is ear punching. The...

Year Published: 2019Topics: Identification MethodAnimal Type: Mouse, Rodent

Citation: Taitt, K. T., Kendall, L. V. 2019. Physiologic stress of ear punch identification compared with restraint only in mice. JAALAS 58(4), 438-442.

Evaluation of a 16-week change cycle for ventilated mouse cages

The methods and conditions for housing research mice have been the subject of many discussions and publications in recent years. At our institution, we began to explore these matters with the goal of reducing stress in the animals and yet...

Year Published: 2019Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Taylor, J. L., Noel, P., Mickelsen, M. 2019. Evaluation of a 16-week change cycle for ventilated mouse cages. JAALAS 58(4), 443-449.

Identifying and implementing endpoints for geriatric mice

The types of changes in physical appearance and behavior that occur in elderly people similarly develop in elderly animals. Signs and symptoms that might cause concern in younger people or mice may be normal in their elderly but generally healthy...

Year Published: 2018Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Toth, L. A. 2018. Identifying and implementing endpoints for geriatric mice. Comparative Medicine 68(6), 439–451.

Monitoring the health status of mice with bleomycin-induced lung injury by using body condition scoring

Well-defined, humane endpoints aid in monitoring animal health status during disease development. Body condition scoring (BCS) is a method for assessing health status in mouse studies where wasting and death are potential endpoints. Whether BCS is useful in monitoring animals...

Year Published: 2019Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Cowley, P. M., Roberts, C. R., Baker, A. J. 2019. Monitoring the health status of mice with bleomycin-induced lung injury by using body condition scoring. Comparative Medicine 69(2), 95–102.

Alfaxalone-xylazine anesthesia in laboratory mice (Mus musculus)

Since its recent reformulation, alfaxalone has gained popularity as an injectable veterinary anesthetic, including promising studies demonstrating the use of alfaxalone-xylazine for anesthesia in mice. Here we sought to expand these studies by testing additional dose ranges, elaborating on physiologic...

Year Published: 2019Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Erickson, R. L., Blevins, C. E., De Souza Dyer, C. et al. 2019. Alfaxalone-xylazine anesthesia in laboratory mice (Mus musculus). JAALAS 58(1), 30-39.