Mouse

Animal handling in containment

As Animal Technologists we are constantly looking at refining and enriching the environmental conditions of all our animals to give them both physical exercise and mental stimulation regardless of their size. However, animals can still experience stress when being moved...

Year Published: 2019Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Zvarev, C., Baker, S., Patel, D. 2019. Animal handling in containment. Animal Technology and Welfare 18(2), 140-142. (IAT Congress 2018 Poster Presentation)

In-vivo imaging at NIBSC and how we use it to promote the 3Rs

In-vivo imaging is a revolutionary technology offering a powerful tool for constructing studies involving mice. In the Biological Services Department (BSD) at NIBSC, the IVIS® Spectrum In Vivo System model is used to perform our studies. Imaging has a wide...

Year Published: 2019Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Gurney, L. 2019. In-vivo imaging at NIBSC and how we use it to promote the 3Rs. Animal Technology and Welfare 18(2), 143-144. (IAT Congress 2018 Poster Presentation)

Report of the Enrichment; Awareness and Uptake Workshop 2018 on 26th June at College Court, Leicester

The point of the session was to have a collaborative discussion about environmental enrichment. The organisers wanted to know people's experiences with enrichment, the barriers they have faced, if they have overcome any, and also to share some of their...

Year Published: 2019Topics: Environmental Enrichment, ReproductionAnimal Type: Mouse, Rat, Rodent

Citation: King, J. 2018. Report of the Enrichment; Awareness and Uptake Workshop 2018 on 26th June at College Court, Leicester. Animal Technology and Wefare 17(3), 163-167. [Meeting Report]

Time’s up for tick-over colonies… Do we now need to maintain so many GA mouse lines?

The practice of continually breeding lines to maintain them as a live resource either in-between studies or indefinitely “just in case” is common practice in many animal facilities. This process of “ticking over” colonies has historically occurred due to the...

Year Published: 2019Topics: ReproductionAnimal Type: Mouse, Rodent

Citation: Newman, S., Woodley, S. 2019. Time's up for tick-over colonies… Do we now need to maintain so many GA mouse lines? Animal Technology and Welfare 17(3), 155-157.

Why are enriched mice nice? Investigating how environmental enrichment reduces agonism in female C57BL/6, DBA/2, and BALB/c mice

Compared to female mice raised in large, environmentally enriched (EE) cages, those from “shoebox” non-enriched (NE) cages demonstrate more stereotypic behaviour (SB) and depressive-like effects (i.e. learned helplessness; and inactive-but-awake behaviour [IBA], where a mouse simply stands still). Past research...

Year Published: 2019Topics: Environmental Enrichment, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Nip, E., Adcock, A., Nazal, B. et al. 2019. Why are enriched mice nice? Investigating how environmental enrichment reduces agonism in female C57BL/6, DBA/2, and BALB/c mice. Applied Animal Behaviour Science 217, 73-82.

Social environment as a cause of litter loss in laboratory mouse: A behavioural study

Perinatal mortality is a widespread problem in laboratory mouse breeding and is often manifested by the loss of the entire litter within the first days of life. High mortality is an animal health and welfare concern that violates the 3R...

Year Published: 2019Topics: Rearing & Weaning, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Brajon, S., Morello, G. M., Teixeira, M. S. et al. 2019. Social environment as a cause of litter loss in laboratory mouse: A behavioural study. Applied Animal Behaviour Science 218, 104827.

Humanely ending the life of animals: Research priorities to identify alternatives to carbon dioxide

The use of carbon dioxide (CO2) for stunning and killing animals is considered to compromise welfare due to air hunger, anxiety, fear, and pain. Despite decades of research, no alternatives have so far been found that provide a safe and...

Year Published: 2019Topics: EuthanasiaAnimal Type: Bird, Chicken, Mouse, Pig, Rat

Citation: Steiner, A. R., Axiak Flammer, S., Beausoleil, N. J. et al. 2019. Humanely ending the life of animals: Research priorities to identify alternatives to carbon dioxide. Animals 9(11), 911.

Parental behavior and anxiety in isogenic and outbred mice given access to two types of nesting materials

The objective was to investigate if providing two types of nesting materials could modulate parental behavior and anxiety in laboratory mice. For that, 54 full-sib BALB/cJ and 50 randomly mated Swiss Webster mouse pairs were employed in a completely randomized...

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Moreira, V. B., Mattaraia, V. G. M., Rodrigues, M. V. et al. 2019. Parental behavior and anxiety in isogenic and outbred mice given access to two types of nesting materials. Applied Animal Behaviour Science 215, 68-76.

Alternatives to carbon dioxide—Taking responsibility for humanely ending the life of animals

Carbon dioxide (CO2) is commonly used to kill rodents. However, a large body of research has now established that CO2 is aversive to them. A multidisciplinary symposium organized by the Swiss Federal Food Safety and Veterinary Office discussed the drawbacks...

Year Published: 2019Topics: EuthanasiaAnimal Type: Chinchilla, Gerbil, Guinea Pig, Hamster, Mouse, Other Rodent, Rat, Rodent

Citation: Axiak Flammer, S., Eskes, C., Kohler, I. et al. 2019. Alternatives to carbon dioxide—Taking responsibility for humanely ending the life of animals. Animals 9(8), 482.

Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale

What is the central question of this study? There is an ethical imperative to optimize analgesia protocols for laboratory animals, but this is impeded by our inability to recognize pain reliably. We examined whether the Mouse Grimace Scale (MGS) provides...

Year Published: 2015Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Faller, K. M., McAndrew, D. J., Schneider, J. E. et al. 2015. Refinement of analgesia following thoracotomy and experimental myocardial infarction using the Mouse Grimace Scale. Experimental Physiology 100(2), 164-172.