Mouse

Validating in-cage mouse enrichment

There is a wide variety of different types of mouse enrichment currently available, some items of which are more practical than others. Validating items used for providing enrichment can be time consuming and costly, nevertheless it is important to ensure...

Year Published: 2023Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Burbidge, C., Beresford, Z., Serrano-Galleg, V. 2023. Validating in-cage mouse enrichment. Animal Technology and Welfare 22(1), 63–67.

The power of a touch: Regular touchscreen training but not its termination affects hormones and behavior in mice

Touchscreen-based procedures are increasingly used in experimental animal research. They not only represent a promising approach for translational research, but have also been highlighted as a powerful tool to reduce potential experimenter effects in animal studies. However, to prepare the...

Year Published: 2023Topics: Animal Training, Behavioral & Cognitive Testing, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Quante, S. M., Siewert, V., Palme, R. et al. 2023. The power of a touch: Regular touchscreen training but not its termination affects hormones and behavior in mice. Frontiers in Behavioral Neuroscience 17, 1112780.

Mouse food hopper dividers for a refined feeding method

This project aimed to establish whether a different method of presenting diet “ad-libitum” to laboratory mice could lower the negative consequences of exceess food, such as decreased quality, palatability and increased cost. The main aim of this project was to...

Year Published: 2022Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Orosz, G. 2022. Mouse food hopper dividers for a refined feeding method. Animal Technology and Welfare 21(3), 160–176.

Longitudinal studies on Alzheimer disease mouse models with multiple tracer PET/CT: Application of reduction and refinement principles in daily practice to safeguard animal welfare during progressive aging

Longitudinal studies on mouse models related to Alzheimer disease (AD) pathology play an important role in the investigation of therapeutic targets to help pharmaceutical research in the development of new drugs and in the attempt of an early diagnosis that...

Year Published: 2023Topics: Disease/Experimental Model, Husbandry & Management, Imaging & Electrophysiological RecordingAnimal Type: Mouse, Rodent

Citation: Palumbo, G., Kunze, L. H., Oos, R. et al. 2023. Longitudinal studies on Alzheimer disease mouse models with multiple tracer PET/CT: Application of reduction and refinement principles in daily practice to safeguard animal welfare during progressive aging. Animals 13(11), 1812.

Using bioluminescence to image gene expression and spontaneous behavior in freely moving mice

Bioluminescence imaging (BLI) of gene expression in live animals is a powerful method for monitoring development, tumor growth, infections, healing, and other progressive, long-term biological processes. BLI remains an effective approach for reducing the number of animals needed to monitor...

Year Published: 2023Topics: Imaging & Electrophysiological RecordingAnimal Type: Mouse, Rodent

Citation: Malik, A., Zavadil, J. A., Geusz, M. E. 2023. Using bioluminescence to image gene expression and spontaneous behavior in freely moving mice. PLOS ONE 18(1), e0279875.

Exposure to soiled bedding reduces abnormal repetitive behaviors in mice

Hygiene management protocols in laboratory mouse husbandries worldwide most commonly employ soiled bedding-exposed sentinel mice to monitor the occurrence of infections in mouse colonies. Using this approach, sentinel mice repeatedly receive a mixture of used bedding, supplied by a variety...

Year Published: 2022Topics: Abnormal/Problematic Behavior, Housing, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Müller, K., Lengheimer, T., Kral-Pointner, J. B. et al. 2022. Exposure to soiled bedding reduces abnormal repetitive behaviors in mice. Frontiers in Behavioral Neuroscience 16, 1062864.

Development of a 3D simulator for training the mouse in utero electroporation

In utero electroporation (IUE) requires high-level training in microinjection through the mouse uterine wall into the lateral ventricle of the mouse brain. Training for IUE is currently being performed in live mice as no artificial models allow simulations yet. This...

Year Published: 2022Topics: Disease/Experimental Model, Drug/Substance Administration, ReproductionAnimal Type: Mouse, Rodent

Citation: Nuber, M., Gonzalez-Uarquin, F., Neufurth, M. et al. 2022. Development of a 3D simulator for training the mouse in utero electroporation. PLOS ONE 17(12), e0279004.

Rating enrichment items by female group-housed laboratory mice in multiple binary choice tests using an RFID-based tracking system

Laboratory mice spend most of their lives in cages, not experiments, so improving housing conditions is a first-choice approach to improving their welfare. Despite the increasing popularity of enrichment, little is known about the benefits from an animal perspective. For...

Year Published: 2023Topics: Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Hobbiesiefken, U., Urmersbach, B., Jaap, A. et al. 2023. Rating enrichment items by female group-housed laboratory mice in multiple binary choice tests using an RFID-based tracking system. PLOS ONE 18(1), e0278709.

Stress evaluation of mouse husbandry environments for improving laboratory animal welfare

Animal welfare is recognized as essential for the coexistence of humans and animals. Considering the increased demand and interest in animal welfare, many methods for improving animal welfare are being devised, but which method reduces animal stress has not been...

Year Published: 2023Topics: Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Lee, G.-H., Kim, K., Jo, W. 2023. Stress evaluation of mouse husbandry environments for improving laboratory animal welfare. Animals 13(2), 249.

Clicker training mice for improved compliance in the catwalk test

The CatWalk test relies on the run of mice across the platform to measure a constant speed with low variation. Mice usually require a stimulus to walk to the end of the catwalk. However, such stimuli are usually aversive and...

Year Published: 2022Topics: Animal Training, Behavioral & Cognitive TestingAnimal Type: Mouse, Rodent

Citation: Dickmann, J., Gonzalez-Uarquin, F., Reichel, S. et al. 2022. Clicker training mice for improved compliance in the catwalk test. Animals 12(24), 3545.