Mouse

Environmental enrichment and social interaction improve cognitive function and decrease reactive oxidative species in normal adult mice

Environmental stimulation and increased social interactions stimulate cognitive performance, while decrease in these parameters can exacerbate cognitive decline as a function of illness, injury, or age. We examined the impact of environmental stimulation and social interactions on cognitive performance in...

Year Published: 2014Topics: Environmental Enrichment, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Doulames, V., Lee, S., Shea, T. B. 2014. Environmental enrichment and social interaction improve cognitive function and decrease reactive oxidative species in normal adult mice. International Journal of Neuroscience 124(5), 369-376.

Effects of housing condition and cage change on characteristics of sleep in mice

Although human subjects are widely used to study sleep and sleep disorders, animals have been invaluable in developing our understanding of the physiology of sleep and underlying mechanisms of sleep disorders. Environmental stimuli are likely to modify sleep in both...

Year Published: 2014Topics: Environmental Enrichment, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Febinger, H.Y., George, A., Priestley, J. et al. 2014. Effects of housing condition and cage change on characteristics of sleep in mice. JAALAS 53(1), 29-37.

Fighting in the home cage: Agonistic encounters and effects on neurobiological markers within the social decision-making network of house mice (Mus musculus)

Inbred strains of mice, such as C57Bl/6, have become preferred animal models for neurobehavioral studies. A main goal in creating inbred lines is to reduce the effects of individual genetic variation on observed phenotypes. Most studies use only males, and...

Year Published: 2014Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Greenberg, G. D., Howerton, C. L., Trainor, B. C. 2014. Fighting in the home cage: Agonistic encounters and effects on neurobiological markers within the social decision-making network of house mice (Mus musculus). Neuroscience Letters 566, 151-155.

Untangling the influences of voluntary running, environmental complexity, social housing and stress on adult hippocampal neurogenesis

Environmental enrichment (EE) exerts powerful effects on brain physiology, and is widely used as an experimental and therapeutic tool. Typical EE paradigms are multifactorial, incorporating elements of physical exercise, environmental complexity, social interactions and stress, however the specific contributions of...

Year Published: 2014Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Gregoire, C., Bonenfant, D., Le Nguyen, A. et al. 2014. Untangling the influences of voluntary running, environmental complexity, social housing and stress on adult hippocampal neurogenesis. PLOS ONE 9(1), e86237.

Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: Implications for interventions based on social enrichment

Several behavioral interventions, based on social enrichment and observational learning are applied in treatment of neuropsychiatric disorders. However, the mechanism of such modulatory effect and the safety of applied methods on individuals involved in social support need further investigation. We...

Year Published: 2014Topics: Husbandry & Management, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Kulesskaya, N., Karpova, N. N., Ma, L. et al. 2014. Mixed housing with DBA/2 mice induces stress in C57BL/6 mice: Implications for interventions based on social enrichment. Frontiers in Behavioral Neuroscience 8, 257.

Enriched environment increases neurogenesis and improves social memory persistence in socially isolated adult mice

Social memory consists of the information necessary to identify and recognize cospecifics and is essential to many forms of social interaction. Social memory persistence is strongly modulated by the animal's experiences. We have shown in previous studies that social isolation...

Year Published: 2014Topics: Environmental Enrichment, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Monteiro, B. M., Moreira, F. A., Massensini, A. R. et al. 2014. Enriched environment increases neurogenesis and improves social memory persistence in socially isolated adult mice. Hippocampus 24(2), 239-248.

Castration promotes welfare in group-housed male Swiss outbred mice maintained in educational institutions

Educational institutions maintain group-housed mice of both sexes for training veterinarians and technicians in husbandry, medication, and sampling procedures. Mice kept in all-male groups may experience poor welfare due to fighting. Castrated mice may be used to replace gonadally intact...

Year Published: 2014Topics: Body Modification/Mutilation, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Vaughan, L. M., Dawson, J. S., Porter, P. R. et al. 2014. Castration promotes welfare in group-housed male Swiss outbred mice maintained in educational institutions. JAALAS 53(1), 38-43.

Pair housing reverses post-stroke depressive behavior in mice

Social isolation (SI) has been linked epidemiologically to high rates of morbidity and mortality following stroke. In contrast, strong social support enhances recovery and lowers stroke recurrence. However, the mechanism by which social support influences stroke recovery has not been...

Year Published: 2014Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Verma, R., Friedler, B. D., Harris, N. M. et al. 2014. Pair housing reverses post-stroke depressive behavior in mice. Behavioural Brain Research 269, 155-163.

The use of the puzzle box as a means of assessing the efficacy of environmental enrichment

Environmental enrichment can dramatically influence the development and function of neural circuits. Further, enrichment has been shown to successfully delay the onset of symptoms in models of Huntington's disease, suggesting environmental factors can evoke a neuroprotective effect against the progressive,...

Year Published: 2014Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: O'Connor, A. M., Burton, T. J., Leamey, C. A. et al. 2014. The use of the puzzle box as a means of assessing the efficacy of environmental enrichment. JoVE (Journal of Visualized Experiments) 94, e52225.

The time-to-integrate-to-nest test as an indicator of wellbeing in laboratory mice

Minimizing and alleviating pain and distress in laboratory mice without compromising the methodologic integrity of research is a crucial goal. However, current methods for welfare assessment in mice are not well suited to cageside checks. In the present study, we...

Year Published: 2014Topics: Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Rock, M. L., Rodriguez, K., Karas, A. Z. et al. 2014. The time-to-integrate-to-nest test as an indicator of wellbeing in laboratory mice. JAALAS 53(1), 24-28.