Mouse

Reporting the implementation of the three Rs in European primate and mouse research papers: Are we making progress? Alternatives to Laboratory Animals 38(6), 495-517

It is now more than 20 years since both Council of Europe Convention ETS123 and EU Directive 86/609/EEC were introduced, to promote the implementation of the Three Rs in animal experimentation and to provide guidance on animal housing and care....

Year Published: 2010Topics: Regulations & Ethical ReviewAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Mouse, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Rodent, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Taylor K. 2010. Reporting the implementation of the three Rs in European primate and mouse research papers: Are we making progress? Alternatives to Laboratory Animals 38(6), 495-517.

Frustration and perseveration in stereotypic captive animals: Is a taste of enrichment worse than none at all?

Stereotypic behaviours are common in animals in impoverished housing, arising from two complementary processes: (1) thwarted attempts to perform motivated behaviours; (2) forebrain dysfunction impeding normal behavioural inhibition. When enriched animals are moved to impoverished housing, they are sometimes protected...

Year Published: 2010Topics: Abnormal/Problematic Behavior, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Latham, N., Mason, G. 2010. Frustration and perseveration in stereotypic captive animals: Is a taste of enrichment worse than none at all? Behavioural Brain Research 211(1), 96-104.

Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment

The idea that qualities acquired from experience can be transmitted to future offspring has long been considered incompatible with current understanding of genetics. However, the recent documentation of non-Mendelian transgenerational inheritance makes such a Lamarckian -like phenomenon more plausible. Here,...

Year Published: 2009Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Arai, J. A., Li, S., Hartley, D. M. et al. 2009. Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment. Journal of Neuroscience 29, 1496-1502.

Into the comfort zone – environmental enrichment for rodent metabolism cages

Several glass shelters for mice are described and demonstrated.

Year Published: 2010Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Collier, R. D. 2010. Into the comfort zone - environmental enrichment for rodent metabolism cages. Animal Technology and Welfare 9, 183-185.

Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice

Brain-derived neurotrophic factor (BDNF) has been reported to play important roles in the modulation of anxiety, mood stabilizers, and pathophysiology of affective disorders. Recently, a single nucleotide polymorphism (SNP) in the BDNF gene (Val66Met) has been found to be associated...

Year Published: 2010Topics: Emotion, Pain, & Sentience, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Li, W. J., Yu, H., Yang, J. M. et al. 2010. Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice. Brain Research 1347, 71-79.

Taming anxiety in laboratory mice

Handling experience (which includes routine maintenance) can have positive or negative effects on stress responses that influence experiments, depending on the animals' experience during handling. The most common method used to capture and handle laboratory mice is to pick up...

Year Published: 2010Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Hurst, J. L., West, R. S. 2010. Taming anxiety in laboratory mice. Nature Methods 7(10), 825-826.

The COST Manual of Laboratory Animal Care and Use: Refinement, Reduction, and Research (1st Ed)

COST Action B-24 established four working groups to research and discuss issues relevant to laboratory animal science. These included the housing of animals, environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based on the groups' findings, The...

Year Published: 2010Topics: Environmental Enrichment, Euthanasia, Handling, Housing, Regulations & Ethical Review, Surgery & Post-OpAnimal Type: Mouse, Rabbit, Rat, Rodent

Citation: Howard, B., Nevalainen, T., Perretta, G. (ed). 2010. The COST Manual of Laboratory Animal Care and Use: Refinement, Reduction, and Research (1st Ed). CRC Press, Boca Raton, FL.

Recognizing and addressing stereotypic behaviors

The combination of mouse igloos and running wheels proved to be highly effective in reducing flipping, circling, and jumping.

Year Published: 2010Topics: Abnormal/Problematic Behavior, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Harper, V., Frey, A., Bradley, D. et al. 2010. Recognizing and addressing stereotypic behaviors. Tech Talk [The Newsletter for Laboratory Animal Science Technicians] 15(4), 2.

Biology and Medicine of Rabbits and Rodents (5th Ed.)

The Biology and Medicine of Rabbits and Rodents provides concise, up - to - date, reasonably comprehensive information to anyone concerned with the health, care, and management of rabbits and rodents. The book is intended for veterinarians, students, technicians, scientists,...

Year Published: 2010Topics: Husbandry & Management, Welfare AssessmentAnimal Type: Chinchilla, Gerbil, Guinea Pig, Hamster, Mouse, Rabbit, Rat, Rodent

Citation: Harkness, J. E., Turner, P. V., Vande Woude, S. et al. 2010. Biology and Medicine of Rabbits and Rodents (5th Ed.). Wiley-Blackwell, Ames, Iowa.

Mouse welfare terms

Year Published: 2010Animal Type: Mouse, Rodent

Citation: Gardiner, M. 2010. Mouse welfare terms. Animal Technology and Welfare 9, 175-176.