Macaque

Assessment of foraging devices as a model for decision-making in nonhuman primate environmental enrichment

Continued progress to move evidence-based best practices into community and regulatory animal welfare standards depends in part on developing common metrics to assess cost, benefit, and relative value. Here we describe a model approach to evidence-based evaluation and an example...

Year Published: 2014Topics: Environmental Enrichment, Husbandry & ManagementAnimal Type: Macaque, Nonhuman Primate

Citation: Bennett, A. J., Perkins, C. M., Harty, N. M. et al. 2014. Assessment of foraging devices as a model for decision-making in nonhuman primate environmental enrichment. JAALAS 53(5), 452-463.

Effects of needle gauge on blood quality and potential for bruising with repeated blood collections in cynomolgus macaques

Obtaining quality blood samples while minimizing animal trauma related to venipuncture continues to be an important area of focus within the laboratory animal environment as it relates to both animal welfare and sample integrity. A review of the literature suggested...

Year Published: 2014Topics: Biological Sampling & Physiological MeasurementAnimal Type: Macaque, Nonhuman Primate

Citation: Schillaci, T. T., Bishop, B. 2014. Effects of needle gauge on blood quality and potential for bruising with repeated blood collections in cynomolgus macaques. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 609-610. (Abstract #P226).

The use of lean management principles to enhance a nonhuman primate environmental enrichment program

Sewage back-up and overflows in the rooms of our primate facility initiated an analysis of the factors contributing to the clogging of the drains. An investigation reviewing the materials responsible for the clogging of the drains revealed that the use...

Year Published: 2014Topics: Environmental Enrichment, Husbandry & ManagementAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Monts de Oca, N., Diaz, L., McMahen, D. et al. 2014. The use of lean management principles to enhance a nonhuman primate environmental enrichment program. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 580-581. (Abstract #P122).

Laboratory animal behavior

The study of laboratory animal behavior has increased steadily over the last decade, with expanding emphasis on a variety of commonly used species. In the United States, this trend was initially focused on species for which there was a regulatory...

Year Published: 2015Topics: Abnormal/Problematic Behavior, Environmental Enrichment, Housing, Human-Animal Interaction, Social Housing & CompanionshipAnimal Type: Baboon, Bird, Capuchin, Cat, Cattle, Chicken, Chimpanzee, Dog, Fowl, Gerbil, Goat, Guinea Pig, Hamster, Lemur, Macaque, Marmoset, Mink, Mouse, Other Nonhuman Primate, Owl Monkey, Rabbit, Rat, Rodent, Sheep, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Bayne, K. A., Beaver, B. V., Mench, J. A. et al. 2015. Laboratory animal behavior. In: Laboratory Animal Medicine, 3rd edition. Fox, J. G., Anderson, L., Otto, G., et al. (eds). Elsevier, Inc., Amsterdam, NL. pp. 1617-1651.

Depressive-like behavioral profiles in captive-bred single- and socially-housed rhesus and cynomolgus macaques: A species comparison

Background: To unravel the causes of major depressive disorder (MDD), the third leading cause of disease burden around the world, ethological animal models have recently been proposed. Our previous studies highlighted a depressive-like profile among single- and socially-housed farm-bred cynomolgus...

Year Published: 2014Topics: Emotion, Pain, & SentienceAnimal Type: Macaque, Nonhuman Primate

Citation: Camus, S. M. J., Rochais, C., Blois-Heulin, C. et al. 2014. Depressive-like behavioral profiles in captive-bred single- and socially-housed rhesus and cynomolgus macaques: A species comparison. Frontiers in Behavioral Neuroscience 8, 47.

Behavioural and physiological effects of housing type on laboratory housed female rhesus macaques (Macaca mulatta)

Due to the despotic nature of rhesus macaques (Macaca mulatta) and their frequent use in biomedical research, it is important to understand the impact that standard housing practices can have on individuals of this species in order to improve practices...

Year Published: 2015Topics: Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Cassidy, L., Semple, S., Hannibal, D. et al. 2015. Behavioural and physiological effects of housing type on laboratory housed female rhesus macaques (Macaca mulatta). Folia Primatologica 86(4), 259-60.

Training pair-housed Rhesus macaques (Macaca mulatta) using a combination of negative and positive reinforcement

When training animals, time is sometimes a limiting factor hampering the use of positive reinforcement training (PRT) exclusively. The aim of this study was to evaluate the effects of a combination of negative and positive reinforcement training (NPRT). Twenty nave...

Year Published: 2015Topics: Animal TrainingAnimal Type: Macaque, Nonhuman Primate

Citation: Wergrd, E., Temrin, H., Forkman, B. et al. 2015. Training pair-housed Rhesus macaques (Macaca mulatta) using a combination of negative and positive reinforcement. Behavioural Processes 113, 51-59.

Effects of group housing on ECG assessment in conscious cynomolgus monkeys

Assessing the cardiovascular safety of new chemical or biological entities is important during pre-clinical development. Electrocardiogram (ECG) assessments in non-human primate (NHP) toxicology studies are often made using non-invasive telemetry systems. We investigated whether ECG recording was feasible during group...

Year Published: 2015Topics: Biological Sampling & Physiological Measurement, External Bodily Equipment, Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Xing, G., Lu, J., Hu, M. et al. 2015. Effects of group housing on ECG assessment in conscious cynomolgus monkeys. Journal of Pharmacological and Toxicological Methods 75, 44-51.

Miniaturized blood sampling techniques to benefit reduction in mice and refinement in nonhuman primates: Application to bioanalysis in toxicity studies with antibody-drug conjugates

Minimizing the number of animals in regulatory toxicity studies while achieving study objectives to support the development of future medicines contributes to good scientific and ethical practices. Recent advances in technology have enabled the development of miniaturized blood sampling methods...

Year Published: 2015Topics: Biological Sampling & Physiological MeasurementAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Mouse, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Rodent, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Caron, A., Lelong, C., Pascual, M. H. et al. 2015. Miniaturized blood sampling techniques to benefit reduction in mice and refinement in nonhuman primates: Application to bioanalysis in toxicity studies with antibody-drug conjugates. JAALAS 54(2), 145-152.

Strategies for successfully social housing incompatible cynomolgus macaque trios

At Charles River, we are committed to ensuring all animals have the highest level of care and welfare. At our facility, the typical study design requires primates to be housed in groups of 3 (or triads). While we have a...

Year Published: 2015Topics: Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Abney, D. M., Moomaw, H. A. 2015. Strategies for successfully social housing incompatible cynomolgus macaque trios. American Journal of Primatology 77(S1), 59-60. (38th Meeting of the American Society of Primatologists Scientific Program, Abstract #65)