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The 3Rs in experimental liver disease

Patients with cirrhosis present multiple physiological and immunological alterations that play a very important role in the development of clinically relevant secondary complications to the disease. Experimentation in animal models is essential to understand the pathogenesis of human diseases and,...

Year Published: 2023Topics: Disease/Experimental ModelAnimal Type: All/General, Mouse, Rat, Rodent

Citation: Martinez-Lopez, S., Angel-Gomis, E., Sanchez-Ardid, E. et al. 2023. The 3Rs in experimental liver disease. Animals 13(14), 2357.

Choice, control, and animal welfare: Definitions and essential inquiries to advance animal welfare science

The ways in which humans can support good welfare for animals in their care is an ongoing subject of debate: some place emphasis on the animals' physical health; others, on animals' ability to live “natural lives”; and others on animals'...

Year Published: 2023Topics: Environmental Enrichment, Natural BehaviorAnimal Type: All/General, Macaque, Nonhuman Primate

Citation: Englund, M. D., Cronin, K. A. 2023. Choice, control, and animal welfare: Definitions and essential inquiries to advance animal welfare science. Frontiers in Veterinary Science 10.

CIRS-LAS – a novel approach to increase transparency in laboratory animal science for improving animal welfare by reducing laboratory animal distress

The 3Rs principle is highly topical in animal-based research. These include, above all, new scientific methods for conducting experiments without an animal model, by using non-animal models (Replace), reducing the number of laboratory animals (Reduction) or taking measures to keep...

Year Published: 2023Topics: Regulations & Ethical ReviewAnimal Type: All/General

Citation: Enkelmann, A., Bischoff, S. J. 2023. CIRS-LAS – a novel approach to increase transparency in laboratory animal science for improving animal welfare by reducing laboratory animal distress. Frontiers in Veterinary Science 10.

Why it hurts: With freedom comes the biological need for pain

We argue that pain is not needed to protect the body from damage unless the organism is able to make free choices in action selection. Then pain (including its affective and evaluative aspects) provides a necessary prioritising motivation to select...

Year Published: 2023Topics: Emotion, Pain, & SentienceAnimal Type: All/General

Citation: Farnsworth, K. D., Elwood, R. W. 2023. Why it hurts: With freedom comes the biological need for pain. Animal Cognition 26(4), 1259–1275.

Fostering animal welfare and advancing 3Rs principles through the establishment of a 3Rsadvisory group

Based on the current state of science, the use of animals remains essential in bringing safe and effective medicines to patients. Respect for laboratory animal welfare and the application of 3Rs principles (the replacement, reduction, and refinement of animal use...

Year Published: 2023Topics: Regulations & Ethical ReviewAnimal Type: All/General

Citation: Graham, J. C., Wong, L., Adedeji, A. O. et al. 2023. Fostering animal welfare and advancing 3Rs principles through the establishment of a 3Rsadvisory group. Animals 13(24), 3863.

Bridging pure cognitive research and cognitive enrichment

Cognitive enrichment is a growing subset of environmental enrichment for captive animals. However, it has been difficult for practitioners to design, implement, and evaluate relevant and appropriate cognitive challenges. Even though pure comparative cognition researchers focus on fundamental evolutionary questions,...

Year Published: 2022Topics: Environmental EnrichmentAnimal Type: All/General

Citation: Clark, F. E. 2022. Bridging pure cognitive research and cognitive enrichment. Animal Cognition 25(6), 1671–1678.

Severity classification of laboratory animal procedures in two Belgian academic institutions

According to the EU Directive 2010/63, all animal procedures must be classified as non-recovery, mild, moderate or severe. Several examples are included in the Directive to help in severity classification. Since the implementation of the Directive, different publications and guidelines...

Year Published: 2023Topics: Regulations & Ethical ReviewAnimal Type: All/General

Citation: De Vleeschauwer, S., Lambaerts, K., Hernot, S. et al. 2023. Severity classification of laboratory animal procedures in two Belgian academic institutions. Animals 13(16), 2581.

Cognitive enrichment and welfare: Current approaches and future directions

Cognitive enrichment” is a subset of enrichment that has gained interest from researchers over the past decade, particularly those working in zoos. This review explores the forms of cognitive enrichment that have been attempted for laboratory, farmed and zoo animals...

Year Published: 2017Topics: Environmental EnrichmentAnimal Type: All/General

Citation: Clark, F. 2017. Cognitive enrichment and welfare: Current approaches and future directions. Animal Behavior and Cognition 4(1), 52–71.

Animal welfare: Could adult play be a false friend?

There is no consensus regarding the functions of play. As play behavior is a characteristic of young stages of development, it has been suggested that the higher prevalence of adult play observed in domestic animals could be the result of...

Year Published: 2015Topics: Natural Behavior, Welfare AssessmentAnimal Type: All/General, Equine, Macaque, Nonhuman Primate

Citation: Blois-Heulin, C., Rochais, C., Camus, S. et al. 2015. Animal welfare: Could adult play be a false friend? Animal Behavior and Cognition 2(2), 156–185.

BrainWAVE: A flexible method for noninvasive stimulation of brain rhythms across species

Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced...

Year Published: 2023Topics: Disease/Experimental ModelAnimal Type: All/General, Mouse, Rodent

Citation: Attokaren, M. K., Jeong, N., Blanpain, L. et al. 2023. BrainWAVE: A flexible method for noninvasive stimulation of brain rhythms across species. ENeuro 10(2) ENEURO.0257-22.2022.