The effects of handling on antibody production, mitogen responses, spleen number, and lymphocyte subpopulations (1990)

Moynihan, J., Brenner, G., Koota, D. et al.

Abstract

The immune response was depressed when mice were picked up by the tail and held gently in the palm without restraint. From the methodological point of view, handling of experimental animals may be a significant uncontrolled factor in many in vivo experiments.