Long-term environmental enrichment leads to regional increase in neurotrophin levels in rat brain (2000)

Ickes, B. R., Pham, T. M., Sanders, L. A. et al.

Abstract

These findings demonstrate significant alterations in NGF, and NT-3 protein levels in several brain regions as a result of an enriched versus an isolated environment and thus provide a possible biochemical basis for behavioral and alterations that have been found to occur with a shifting environmental stimulus.