Floor space needs for laboratory mice: C57BL/6 males in solid-bottom cages with bedding (1998)

Fullwood, S., Hicks, T. A., Brown, J. C. et al.

Abstract

Different floor space allocations of cages that were barren except bedding were tested in groups of 3 male mice. Space reduction - from 129 to 32 square cm per mouse - had no impact on body weight gain; but with smaller floor spaces, mice appeared to use more feed and water. We attributed the increase feed and water use to greater feed wastage. ... Mouse mortality [resulting from bite and attack wounds] was greater as more space was provided. In contrast, adrenal weights and plasma glucocorticoid concentrations were progressively greater with lower space allowance. The authors concluded that socially housed male C57BL/6 mice will benefit from less space than recommended by the NRC in 1996 [Guide for the Care and Use of Laboratory Animals].