Effect of stress on pharmocokinetics of amikacin and ticarcillin (1987)

Shyu, W. C., Nightingale, C. H., Tsuji, A. et al.

Abstract

Aberrant serum ticarcillin concentrations were measured when the animals were simply picked out, put on a laboratory bench, and wrapped in a towel to restrain them for blood collection. No aberration occurred in quasi trained rats who were handled daily for 3-4 d prior to study and then held and petted by the investigator throughout the experimental period. No towel was needed to restrain these rats. In the amikacin group, 'trained' rats showed a much slower absorption process compared with conventionally handled rats. Alterations in renal flow due to the stress resulting from the traditional handling procedure may have affected pharmocokinetics.