Circadian alteration of audiogenic seizure susceptibility in rats (1970)

Wada, J. A., Asakura, T.

Abstract

Genetically determined audiogenic seizure susceptibility in Wistar albino rats showed distinct rhythmicity with its increase and decrease during night and day, respectively. This rhythmicity is apparently regulated by light since its trend can be readily reversed by artificially reversing the illumination pattern of day-night schedule in their colony. This is best observed in rats which are arbitrarily classified as nonsensitive with no response to six day-time audiogenic stimulations on alternate days.