Mouse

Effects of breeding configuration on behavior, reproduction, and pathology in the laboratory mouse (Mus musculus)

While numerous published studies have evaluated the effect of housing density on the wellbeing of laboratory mice, little is known on the effect of breeding configuration. The eighth edition of the Guide for the Care and Use of Laboratory Animals...

Year Published: 2014Topics: ReproductionAnimal Type: Mouse, Rodent

Citation: Braden, G.C., Rasmussen, S., Tolwani, R.J. 2014. Effects of breeding configuration on behavior, reproduction, and pathology in the laboratory mouse (Mus musculus). American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 605. (Abstract #P210).

Refining blood collection techniques to improve animal welfare and sample quality

An effort to refine rodent blood collection techniques resulted in an examination of alternative methodologies to improve animal welfare and sample quality. Disease model or repeated sample collection resulted in inadequate sample volume, occasional hemolysis, and complications including bruising, scarring,...

Year Published: 2014Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Allaire. A. C., Boule, S. 2014. Refining blood collection techniques to improve animal welfare and sample quality. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 605-606. (Abstract #P212).

Refinement and efficiency through serial microsampling: Cost:benefit analysis

Advances in bioanalytic methods allow for accurate plasma drug level measurement in small sample volumes. Decreased sample volumes enable serial blood sample collection from one rodent, rather than terminal or sparse sampling from multiple rodents. Decreased variability in data from...

Year Published: 2014Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Bratcher, N. A., Ebert, P. A., Buck, W. et al. 2014. Refinement and efficiency through serial microsampling: Cost:benefit analysis. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 580. (Abstract #P121).

An innovative restraint device for the placement of intravenous tail vein catheters in anesthetized mice

Consistently accurate intravenous tail vein administration of radiopharmaceuticals in anesthetized mice is a critical component of successful PET/CT imaging in the preclinical setting. Injectable anesthetics are often not suitable for PET imaging and commercially available mouse restraint devices do not...

Year Published: 2014Topics: Biological Sampling & Physiological Measurement, RestraintAnimal Type: Mouse, Rodent

Citation: Tupper, T., Manning, H., Turner, D. et al. 2014. An innovative restraint device for the placement of intravenous tail vein catheters in anesthetized mice. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 584. (Abstract #P136).

Minimizing symptoms and stress in seizure-prone mice by using acupressure during routine handling

Many laboratory mice used in research experience spontaneous seizures during cage changing and routine handling. The triggers are usually the abrupt sound and sudden motion of the cage. These seizures can range from mild to severe, often resulting in uncontrollable...

Year Published: 2014Topics: Handling, Human-Animal InteractionAnimal Type: Mouse, Rodent

Citation: Young, M., Lawson, G. W., Duarte-Vogel, S. et al. 2014. Minimizing symptoms and stress in seizure-prone mice by using acupressure during routine handling. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 555 (Abstract #P29).

Refining methods for mouse hepatic biopsy

The mouse is a commonly used species in liver research such as oncology, toxicology, and disease models. The ability to collect specimens of liver is vital to such research. Such studies require either a major surgical procedure or euthanasia to...

Year Published: 2014Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Torres, M. 2014. Refining methods for mouse hepatic biopsy. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 557-558 (Abstract #P32).

Responses by wild house mice (Mus musculus) to various stimuli in a novel environment

House mice (Mus musculus) pose a threat to the native flora and fauna on islands, and can cause significant damage wherever they have been introduced. Methods used to eradicate invasive rodents, like house mice, at high population densities may not...

Year Published: 2014Topics: Natural BehaviorAnimal Type: Mouse, Rodent

Citation: Witme, G. W., Snow, N. P., Moulton, R. S. 2014. Responses by wild house mice (Mus musculus) to various stimuli in a novel environment. Applied Animal Behaviour Science 159, 99-106.

What is the impact of low testosterone levels on the anatomical and behavioral repertoire of long-term enriched housing of male mice? Behavioral Processes 108, 57-64

Environmental enrichment is a strategy to improve animal welfare, providing brain plasticity with changes at cellular, molecular and behavioral levels. In order to test the long-term effects of enriched housing and the importance of testosterone levels for the expression of...

Year Published: 2014Topics: Environmental Enrichment, ReproductionAnimal Type: Mouse, Rodent

Citation: Lima, F. B., de Oliveira, E. S. 2014. What is the impact of low testosterone levels on the anatomical and behavioral repertoire of long-term enriched housing of male mice? Behavioral Processes 108, 57-64.

Use of vinyl nonadhesive tape as an alternative for positioning rodents in small animal imaging

Specific positioning for different imaging modalities is essential in our small animal imaging core. While we have different animal holders designed to position the animal inside the MRI, additional securing of the animal to the holder is needed. Adjustments also...

Year Published: 2014Topics: Imaging & Electrophysiological Recording, RestraintAnimal Type: Gerbil, Hamster, Mouse, Rat, Rodent

Citation: Bode, A. E., Barber, H. 2014. Use of vinyl nonadhesive tape as an alternative for positioning rodents in small animal imaging. American Association for Laboratory Animal Science [AALAS] Meeting Official Program, 597-598. (Abstract #P185).

Stereotypic mice are aggressed by their cage-mates and tend to be poor demonstrators in social learning tasks

Stereotypic behaviours (SBs) are linked with behavioural inflexibility and resemble symptoms of autism, suggesting that stereotypic animals could have autistic-like social impairments. SBs are also common in caged mice. We therefore hypothesised relationships between stereotypic and social behaviours, predicting that...

Year Published: 2015Topics: Abnormal/Problematic Behavior, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Harper, L., Choleris, E., Ervin, K. et al. 2015. Stereotypic mice are aggressed by their cage-mates and tend to be poor demonstrators in social learning tasks. Animal Welfare. 24(4), 463-473.