Macaque

Minimally invasive lumbar port system for the collection of cerebrospinal fluid from rhesus macaques (Macaca mulatta)

Biomedical translational research frequently incorporates collection of CSF from NHP, because CSF drug levels are used as a surrogate for CNS tissue penetration in pharmacokinetic and dynamic studies. Surgical placement of a CNS ventricular catheter reservoir for CSF collection is...

Year Published: 2016Topics: Biological Sampling & Physiological MeasurementAnimal Type: Macaque, Nonhuman Primate

Citation: MacAllister, R. P., Lester McCully, C. M., Bacher, J. et al. 2016. Minimally invasive lumbar port system for the collection of cerebrospinal fluid from rhesus macaques (Macaca mulatta). Comparative Medicine 66(4), 349–352.

An international survey of approaches to chair restraint of nonhuman primates

Specifically designed restraint chairs are the preferred method of restraint for research studies that require NHP to sit in place for sustained periods of time. In light of increasing emphasis on refinement of restraint to improve animal wellbeing, it is...

Year Published: 2017Topics: RestraintAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Squirrel Monkey, Vervet (African Green Monkey)

Citation: McMillan, J. L., Bloomsmith, M. A., Prescott, M. J. 2017. An international survey of approaches to chair restraint of nonhuman primates. Comparative Medicine 67(5), 442–451.

Hypercortisolemia and depressive-like behaviors in a rhesus macaque (Macaca mulatta) involved in visual research

A 10-y-old cranially implanted rhesus macaque (Macaca mulatta) involved in visual research was presented for dull mentation and weight loss. Physical examination revealed alopecia and poor body conditioning, and bloodwork revealed marked hypercortisolemia (23 μg/dL). Differential diagnoses for hypercortisolemia, weight...

Year Published: 2017Topics: Emotion, Pain, & Sentience, Environmental EnrichmentAnimal Type: Macaque, Nonhuman Primate

Citation: Adams, S. C., Guyot, C. M., Berry, K. M. et al. 2017. Hypercortisolemia and depressive-like behaviors in a rhesus macaque (Macaca mulatta) involved in visual research. Comparative Medicine 67(6), 529–536.

Retrospective review of surgical outcomes and pair-housing success in vasectomized rhesus macaques (Macaca mulatta)

Providing social housing for adult male macaques can be challenging. One successful strategy for long-term social housing of adult male macaques is to pair them with adult females; however, unwanted breeding must be prevented by sterilization of the male or...

Year Published: 2018Topics: Reproduction, Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Ekanayake-Alper,D. K., Wilson, S. R., Scholz, J. A. 2018. Retrospective review of surgical outcomes and pair-housing success in vasectomized rhesus macaques (Macaca mulatta). Comparative Medicine 68(2), 168–176.

Social management of laboratory rhesus macaques housed in large groups using a network approach: A review

Biomedical facilities across the nation and worldwide aim to develop cost-effective methods for the reproductive management of macaque breeding groups, typically by housing macaques in large, multi-male multi-female social groups that provide monkey subjects for research as well as appropriate...

Year Published: 2018Topics: Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: McCowan, B., Beisner, B., Hannibal, D. 2018. Social management of laboratory rhesus macaques housed in large groups using a network approach: A review. Behavioural Processes 156, 77-82.

Systematic assessment of food item preference and reinforcer effectiveness: Enhancements in training laboratory-housed rhesus macaques

The use of systematic preference assessments can enhance positive reinforcement training with captive animals. We found that the multiple stimulus without replacement (MSWO) technique identified food preferences in laboratory housed rhesus macaques, with raisins and grapes being ranked higher on...

Year Published: 2018Topics: Animal TrainingAnimal Type: Macaque, Nonhuman Primate

Citation: Martin, A. L., Franklin, A. N., Perlman, J. E. et al. 2018. Systematic assessment of food item preference and reinforcer effectiveness: Enhancements in training laboratory-housed rhesus macaques. Behavioural Processes 157, 445-452.

Preliminary validation of natural depression in macaques with acute treatments of the fast-acting antidepressant ketamine

Non-human primates have become one of the most important model animals for the investigation of brain diseases because they share a wide-range of genetics and social similarities with human beings. Naturally-evoked depression models in macaques may offer a full spectrum...

Year Published: 2019Topics: Emotion, Pain, & SentienceAnimal Type: Macaque, Nonhuman Primate

Citation: Chu, X. 2019. Preliminary validation of natural depression in macaques with acute treatments of the fast-acting antidepressant ketamine. Behavioural Brain Research 360, 60-68.

A computerized testing system for primates: Cognition, welfare, and the Rumbaughx

Innovations in apparatus technology come about for a variety of reasons such as the need to use the same methodology with various species, the opportunity to present dynamic and carefully controlled stimuli, the goal of using automation to make data...

Year Published: 2018Topics: Environmental EnrichmentAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Perdue, B. M., Beran, M. J., Washburn, D. A. 2018. A computerized testing system for primates: Cognition, welfare, and the Rumbaughx. Behavioural Processes 156, 37-50.

Testing the weekend effect hypothesis: Time of day and lunar phase better predict the timing of births in laboratory‐housed primates than day of week

The weekend effect hypothesis proposes that captive primates are more likely to give birth during times of low disturbance and reduced staff activity. The hypothesis specifically predicts that laboratory‐housed primates will be more likely to give birth during the weekend...

Year Published: 2019Topics: ReproductionAnimal Type: Macaque, Nonhuman Primate, Owl Monkey, Squirrel Monkey

Citation: Hopper, L. M., Fernandez‐Duque, E., Williams, L. E. 2019. Testing the weekend effect hypothesis: Time of day and lunar phase better predict the timing of births in laboratory‐housed primates than day of week. American Journal of Primatology 81(7), e23026.

Oxytocin and pair compatibility in adult male rhesus macaques (Macaca mulatta)

Pair housing is considered one of the best ways of promoting psychological wellbeing for caged macaques. However, incompatible partnerships can result in stress or aggression. Though previous studies have analyzed the role of variables such as age, weight, gender, and...

Year Published: 2019Topics: Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Berg, M. R., Heagerty, A., Coleman, K. 2019. Oxytocin and pair compatibility in adult male rhesus macaques (Macaca mulatta). American Journal of Primatology 81(8), e23031.