Macaque

Depressive-like behavioral profiles in captive-bred single- and socially-housed rhesus and cynomolgus macaques: A species comparison

Background: To unravel the causes of major depressive disorder (MDD), the third leading cause of disease burden around the world, ethological animal models have recently been proposed. Our previous studies highlighted a depressive-like profile among single- and socially-housed farm-bred cynomolgus...

Year Published: 2014Topics: Emotion, Pain, & SentienceAnimal Type: Macaque, Nonhuman Primate

Citation: Camus, S. M. J., Rochais, C., Blois-Heulin, C. et al. 2014. Depressive-like behavioral profiles in captive-bred single- and socially-housed rhesus and cynomolgus macaques: A species comparison. Frontiers in Behavioral Neuroscience 8, 47.

Behavioural and physiological effects of housing type on laboratory housed female rhesus macaques (Macaca mulatta)

Due to the despotic nature of rhesus macaques (Macaca mulatta) and their frequent use in biomedical research, it is important to understand the impact that standard housing practices can have on individuals of this species in order to improve practices...

Year Published: 2015Topics: Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Cassidy, L., Semple, S., Hannibal, D. et al. 2015. Behavioural and physiological effects of housing type on laboratory housed female rhesus macaques (Macaca mulatta). Folia Primatologica 86(4), 259-60.

Training pair-housed Rhesus macaques (Macaca mulatta) using a combination of negative and positive reinforcement

When training animals, time is sometimes a limiting factor hampering the use of positive reinforcement training (PRT) exclusively. The aim of this study was to evaluate the effects of a combination of negative and positive reinforcement training (NPRT). Twenty nave...

Year Published: 2015Topics: Animal TrainingAnimal Type: Macaque, Nonhuman Primate

Citation: Wergrd, E., Temrin, H., Forkman, B. et al. 2015. Training pair-housed Rhesus macaques (Macaca mulatta) using a combination of negative and positive reinforcement. Behavioural Processes 113, 51-59.

Effects of group housing on ECG assessment in conscious cynomolgus monkeys

Assessing the cardiovascular safety of new chemical or biological entities is important during pre-clinical development. Electrocardiogram (ECG) assessments in non-human primate (NHP) toxicology studies are often made using non-invasive telemetry systems. We investigated whether ECG recording was feasible during group...

Year Published: 2015Topics: Biological Sampling & Physiological Measurement, External Bodily Equipment, Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Xing, G., Lu, J., Hu, M. et al. 2015. Effects of group housing on ECG assessment in conscious cynomolgus monkeys. Journal of Pharmacological and Toxicological Methods 75, 44-51.

Miniaturized blood sampling techniques to benefit reduction in mice and refinement in nonhuman primates: Application to bioanalysis in toxicity studies with antibody-drug conjugates

Minimizing the number of animals in regulatory toxicity studies while achieving study objectives to support the development of future medicines contributes to good scientific and ethical practices. Recent advances in technology have enabled the development of miniaturized blood sampling methods...

Year Published: 2015Topics: Biological Sampling & Physiological MeasurementAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Mouse, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Rodent, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Caron, A., Lelong, C., Pascual, M. H. et al. 2015. Miniaturized blood sampling techniques to benefit reduction in mice and refinement in nonhuman primates: Application to bioanalysis in toxicity studies with antibody-drug conjugates. JAALAS 54(2), 145-152.

Strategies for successfully social housing incompatible cynomolgus macaque trios

At Charles River, we are committed to ensuring all animals have the highest level of care and welfare. At our facility, the typical study design requires primates to be housed in groups of 3 (or triads). While we have a...

Year Published: 2015Topics: Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Abney, D. M., Moomaw, H. A. 2015. Strategies for successfully social housing incompatible cynomolgus macaque trios. American Journal of Primatology 77(S1), 59-60. (38th Meeting of the American Society of Primatologists Scientific Program, Abstract #65)

Judgments of monkey’s (Macaca mulatta) facial expressions by humans: Does housing condition “”affect”” countenance?

The ability to interpret facial expressions of others is one of the more important abilities possessed by humans. However, is it possible for humans to interpret the facial expressions of another species of primate accurately, namely rhesus monkeys (Macaca mulatta)?...

Year Published: 2015Topics: Welfare AssessmentAnimal Type: Macaque, Nonhuman Primate

Citation: Gulledge, J. P., Fernandez-Carriba, S., Rumbaugh, D.M. et al. 2015. Judgments of monkey's (Macaca mulatta) facial expressions by humans: Does housing condition "affect" countenance? The Psychological Record 65(1), 203-207.

Telemetric assessment of social and single housing: Evaluation of electrocardiographic intervals in jacketed cynomolgus monkeys

Introduction: Proactive efforts to socially house laboratory animals are a contemporary, important focus for enhancing animal welfare. Jacketing cynomolgus monkeys has been traditionally considered an exclusionary criterion for social housing based on unsubstantiated concerns that study conduct or telemetry equipment...

Year Published: 2015Topics: Biological Sampling & Physiological Measurement, Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Kaiser, R. A., Tichenor, S. D., Regalia, D. E. et al. 2015. Telemetric assessment of social and single housing: Evaluation of electrocardiographic intervals in jacketed cynomolgus monkeys. Journal of Pharmacological and Toxicological Methods 75, 38-43.

Evaluation of environmental and intrinsic factors that contribute to stereotypic behavior in captive rhesus macaques (Macaca mulatta)

Full body repetitive behaviors, known as motor stereotypic behaviors (MSBs), are one of the most commonly seen abnormal behaviors in captive non-human primates, and are frequently used as a behavioral measure of well-being. The main goal of this paper was...

Year Published: 2015Topics: Abnormal/Problematic Behavior, Environmental Enrichment, Social Housing & CompanionshipAnimal Type: Macaque, Nonhuman Primate

Citation: Gottlieb D. H., Maier, A., Coleman, K. 2015. Evaluation of environmental and intrinsic factors that contribute to stereotypic behavior in captive rhesus macaques (Macaca mulatta). Applied Animal Behaviour Science 171,184-91.